...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Neurochemical and behavioural indices of exercise reward are independent of exercise controllability
【24h】

Neurochemical and behavioural indices of exercise reward are independent of exercise controllability

机译：运动奖励的神经化学和行为指标与运动可控性无关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Brain reward circuits are implicated in stress-related psychiatric disorders. Exercise reduces the incidence of stress-related disorders, but the contribution of exercise reward to stress resistance is unknown. Exercise-induced stress resistance is independent of exercise controllability; both voluntary running (VR) and forced running (FR) protect rats against the anxiety-like and depression-like behavioural consequences of stress. Voluntary exercise is a natural reward, but whether rats find FR rewarding is unknown. Moreover, the contribution of dopamine (DA) and striatal reward circuits to exercise reward is not well characterized. Adult, male rats were assigned to locked wheels, VR, or FR groups. FR rats were forced to run in a pattern resembling the natural wheel running behavior of rats. Both VR and FR increased the reward-related plasticity marker Delta FosB in the dorsal striatum and nucleus accumbens, and increased the activity of DA neurons in the lateral ventral tegmental area, as revealed by immunohistochemistry for tyrosine hydroxylase and pCREB. Both VR and FR rats developed conditioned place preference (CPP) to the side of a CPP chamber paired with exercise. Re-exposure to the exercise-paired side of the CPP chamber elicited conditioned increases in cfos mRNA in direct-pathway (dynorphin-positive) neurons in the dorsal striatum and nucleus accumbens in both VR and FR rats, and in tyrosine hydroxylase-positive neurons in the lateral ventral tegmental area of VR rats only. The results suggest that the rewarding effects of exercise are independent of exercise controllability and provide insight into the DA and striatal circuitries involved in exercise reward and exercise-induced stress resistance.
机译：脑奖赏回路与压力相关的精神疾病有关。锻炼可以减少与压力有关的疾病的发生，但是锻炼奖励对抵抗压力的作用尚不清楚。运动引起的压力抵抗力与运动可控制性无关。自愿奔跑（VR）和强迫奔跑（FR）都可以保护大鼠免受压力引起的焦虑和抑郁之类的行为后果。自愿锻炼是一种自然的奖励，但是尚不清楚大鼠是否发现FR奖励。此外，多巴胺（DA）和纹状体奖励回路对行使奖励的贡献还没有很好地描述。将成年雄性大鼠分为锁车轮组，VR组或FR组。 FR大鼠被迫以类似于大鼠自然轮滑行为的方式奔跑。酪氨酸羟化酶和pCREB的免疫组织化学显示，VR和FR均增加了纹状体背侧和伏隔核中与奖励相关的可塑性标记Delta FosB，并增加了腹侧外侧被盖区的DA神经元活性。 VR和FR大鼠均在与运动配对的CPP室一侧形成条件位置偏爱（CPP）。再次暴露于CPP室的运动配对侧会导致VR和FR大鼠以及酪氨酸羟化酶阳性神经元的背侧纹状体和伏隔核直路径（强啡肽阳性）神经元中cfos mRNA的条件性增加仅在VR大鼠的外侧腹侧被盖区。结果表明，锻炼的奖励作用与锻炼可控性无关，并且可以深入了解参与锻炼奖励和运动诱发的压力抵抗的DA和纹状体回路。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号