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首页> 外文期刊>The European Journal of Neuroscience >Nucleus accumbens core and shell are differentially involved in general and outcome-specific forms of Pavlovian-instrumental transfer with alcohol and sucrose rewards
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Nucleus accumbens core and shell are differentially involved in general and outcome-specific forms of Pavlovian-instrumental transfer with alcohol and sucrose rewards

机译：伏伏核的核和壳通过酒精和蔗糖奖赏差异地参与一般形式和特定于结果的巴甫洛夫式器械转移

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摘要

Alcohol-associated stimuli contribute to relapse risk. Therefore, understanding the behavioural and neural mechanisms underlying the ability of such stimuli to promote alcohol-seeking is important for developing effective treatments for alcohol-use disorders. The Pavlovian-instrumental transfer (PIT) paradigm can be used to study the influence of Pavlovian cues on independently-trained instrumental responses earning reward. The effects can be either general, increasing the vigour of reward-related behaviours, or specific to responses that earn a common outcome. These different forms of PIT are mediated by distinct neural circuits involving the nucleus accumbens (NAC) core and shell, respectively. Here we examined the effects of pharmacological inactivation of either the NAC core or shell on PIT generated by alcohol-predictive and sucrose-predictive stimuli in rats. We found that presentations of a stimulus predicting sucrose enhanced responding for sucrose but not alcohol, suggesting an outcome-specific effect. In contrast, presentations of an alcohol-predictive stimulus enhanced responding for both alcohol and sucrose, suggesting a generally arousing effect. Inactivation of the NAC core reduced PIT and, in particular, the effect of the alcohol stimulus. Inactivation of the NAC shell reduced the specificity of the stimulus effects but left the ability of the stimuli to non-specifically invigorate responding intact, consistent with a role in mediating the specificity of PIT. Together, these results suggest that the NAC core plays a particularly important role in mediating the influence of alcohol-predictive cues on reward-seeking behaviours.
机译：酒精相关刺激会增加复发风险。因此，了解这种刺激促进寻求酒精的能力的行为和神经机制对于开发有效的酒精使用障碍治疗很重要。巴甫洛夫式工具转移（PIT）范式可用于研究巴甫洛夫式线索对获得独立奖励的独立训练的乐器反应的影响。其影响可能是普遍的，增加了与奖励相关的行为的活力，也可能是特定于获得共同结果的响应。这些不同形式的PIT由分别涉及伏伏核（NAC）核和壳的不同神经回路介导。在这里，我们检查了NAC核或壳的药理学失活对大鼠酒精预测和蔗糖预测刺激产生的PIT的影响。我们发现，预测蔗糖刺激的表现增强了对蔗糖的反应，但对酒精的反应却不增强，提示了特定结果的作用。相比之下，酒精预测刺激的表现增强了酒精和蔗糖的反应，表明总体上具有刺激作用。 NAC核心的失活减少了PIT，尤其是酒精刺激的作用。 NAC壳的失活降低了刺激作用的特异性，但留下了刺激非特异性激发完整反应的能力，这与介导PIT特异性的作用一致。总之，这些结果表明，NAC核心在调解酒精预测线索对寻求奖励行为的影响方面起着特别重要的作用。

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