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首页> 外文期刊>The European Journal of Neuroscience >Electroconvulsive seizures increase hippocampal neurogenesis after chronic corticosterone treatment.
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Electroconvulsive seizures increase hippocampal neurogenesis after chronic corticosterone treatment.

机译：慢性皮质酮治疗后，电惊厥发作会增加海马神经发生。

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Major depression is often associated with elevated glucocorticoid levels. High levels of glucocorticoids reduce neurogenesis in the adult rat hippocampus. Electroconvulsive seizures (ECS) can enhance neurogenesis, and we investigated the effects of ECS in rats where glucocorticoid levels were elevated in order to mimic conditions seen in depression. Rats given injections of corticosterone or vehicle for 21 days were at the end of this period treated with either a single or five daily ECSs. Proliferating cells were labelled with bromodeoxyuridine (BrdU). After 3 weeks, BrdU-positive cells in the dentate gyrus were quantified and analyzed for co-labelling with the neuronal marker neuron-specific nuclear protein (NeuN). In corticosterone-treated rats, neurogenesis was decreased by 75%. This was counteracted by a single ECS. Multiple ECS further increased neurogenesis and no significant differences in BrdU/NeuN positive cells were detected between corticosterone- and vehicle-treated rats given five ECS. Approximately 80% of the cells within the granule cell layer and 10% of the hilar cells were double-labelled with BrdU and NeuN. We therefore conclude that electroconvulsive seizures can increase hippocampal neurogenesis even in the presence of elevated levels of glucocorticoids. This further supports the hypothesis that induction of neurogenesis is an important event in the action of antidepressant treatment.
机译：严重抑郁症通常与糖皮质激素水平升高有关。高水平的糖皮质激素会降低成年大鼠海马中的神经发生。电惊厥性癫痫发作（ECS）可以增强神经发生，我们研究了ECS在糖皮质激素水平升高以模拟抑郁症中的大鼠中的作用。在此阶段结束时，接受皮质酮或媒介物注射21天的大鼠每天接受一次或每天5次ECS治疗。增殖细胞用溴脱氧尿苷（BrdU）标记。 3周后，对齿状回中的BrdU阳性细胞进行定量分析，并与神经元标记物神经元特异性核蛋白（NeuN）共标记。在接受皮质酮治疗的大鼠中，神经发生减少了75％。这由单个ECS抵消。多个ECS进一步增加了神经发生，在给予5个ECS的皮质酮和媒介物治疗大鼠之间，未检测到BrdU / NeuN阳性细胞的显着差异。颗粒细胞层内约80％的细胞和10％的肺门细胞被BrdU和NeuN双重标记。因此，我们得出结论，即使在糖皮质激素水平升高的情况下，电惊厥性癫痫发作仍可增加海马神经发生。这进一步支持了以下假设：神经发生的诱导是抗抑郁药治疗作用中的重要事件。

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