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首页> 外文期刊>The European Journal of Neuroscience >Development of two transmitter release components during the critical period for imprinting in the chick IMHV.
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Development of two transmitter release components during the critical period for imprinting in the chick IMHV.

机译：在印记在小鸡IMHV的关键时期，开发了两个发射器释放组件。

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摘要

Transmitter release at an excitatory synapse has two components, fast synchronous and slow asynchronous transmitter release. Using the whole cell recording technique, we investigated the developmental properties of neurotransmitter release, which is composed of the two components in the intermediate and medial part of the hyperstriatum ventral (IMHV) of chicks during the critical period for imprinting. Analysis of the paired-pulse responses revealed that the depression of the excitatory postsynaptic currents (EPSCs), driven mainly by fast synchronous release, was frequently observed in P0-1 chicks but not in those at P5-8. The spontaneous excitatory postsynaptic currents (sEPSCs) after the paired-pulse stimulation, which were thought to be driven by asynchronous transmitter releases, were observed more frequently in P0-1 chicks than P5-8 chicks. Furthermore, examination of Ca2+ dependency in the evoked EPSCs showed that the amplitudes in P5-8 chicks were more sensitive to reduction of the extracellular Ca2+ concentration than younger chicks. Considering that the Ca2+ dependency of EPSCs is defined by both Ca2+ sensitivity and the proportion of each type of release machineries at the release site, these results indicate that the ratio of fast synchronous to slow asynchronous transmitter release machinery changed during the critical period. These changes may play critical roles in the capacity of the avian brain to consolidate novel experience in the immediate period after hatching.
机译：兴奋性突触中的发射器释放有两个部分，快速同步释放和慢速异步释放。使用全细胞记录技术，我们研究了神经递质释放的发育特性，该递质由雏鸡在压印关键时期的超纹状体腹侧（IMHV）的中间和中间部分中的两个组件组成。对成对脉冲响应的分析表明，主要由快速同步释放驱动的兴奋性突触后突触电流（EPSC）的降低在P0-1雏鸡中经常观察到，而在P5-8雏鸡中却没有观察到。配对脉冲刺激后的自发性兴奋性突触后电流（sEPSCs）被认为是由异步递质释放驱动的，在P0-1雏鸡中比在P5-8雏鸡中观察到更多。此外，对诱发的EPSCs中Ca 2+依赖性的检查显示，与年轻的雏鸡相比，P5-8雏鸡的振幅对细胞外Ca 2+浓度的降低更敏感。考虑到EPSC的Ca2 +依赖性是由Ca2 +敏感性和释放位置上每种类型的释放机械的比例共同定义的，这些结果表明，快速同步与慢速异步变送器释放机械的比率在关键时期发生了变化。这些变化可能在孵化后立即在禽脑巩固新经验的能力中发挥关键作用。

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