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首页> 外文期刊>The European Journal of Neuroscience >The postnatal reorganization of primary afferent input and dorsal horn cell receptive fields in the rat spinal cord is an activity-dependent process.
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The postnatal reorganization of primary afferent input and dorsal horn cell receptive fields in the rat spinal cord is an activity-dependent process.

机译：大鼠脊髓中主要传入输入和背角细胞感受野的产后重组是一个与活动有关的过程。

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摘要

The dorsal horn of the spinal cord in the newborn rat is characterized by large cutaneous mechanoreceptive fields, a predominance of A-fibre synaptic inputs and diffuse primary afferent A-fibre projections, all of which are gradually reduced and refined over the first postnatal weeks. This may be partly responsible for the reduction in cutaneous flexion reflex sensitivity of rats over the postnatal period. Here we show that chronic, local exposure of the dorsal horn of the lumbar spinal cord to the NMDA antagonist MK801 from birth prevents the normal functional and structural reorganization of A-fibre connections. Dorsal horn cells in spinal MK801-treated animals, investigated at eight weeks of age by in vivo electrophysiological recording, had significantly larger cutaneous mechanoreceptive fields and greater A-fibre evoked responses than vehicle controls. C-fibre evoked responses were unaffected. Chronic MK801 also prevented the normal structural reorganization of A-fibre terminals in the spinal cord. The postnatal withdrawal of superficially projecting A-fibre primary afferents to deeper laminae did not occur in treated animals although C-fibre afferent terminals and cell density in the dorsal horn were apparently unaffected. Spinal MK801-treated animals also had significantly reduced behavioural reflex thresholds to mechanical stimulation of the hindpaw compared to naive and vehicle-treated animals, whereas noxious heat thresholds remained unaffected. The results indicate that the normal postnatal structural and functional development of A-fibre sensory connectivity within the spinal cord is an activity-dependent process requiring NMDA receptor activation.
机译：新生大鼠脊髓背角的特征是较大的皮肤机械感受野，占主导地位的A纤维突触输入和弥散的初级传入A纤维投射，所有这些在出生后的头几周逐渐减少和完善。这可能是造成出生后大鼠的皮肤屈曲反射敏感性降低的部分原因。在这里，我们表明，从出生起，慢性脊髓性腰椎背角局部暴露于NMDA拮抗剂MK801会阻止A纤维连接的正常功能和结构重组。通过体内电生理记录在八周大的年龄进行研究，对经脊髓MK801处理的动物的背角细胞具有比媒介物对照组更大的皮肤机械感受野和更大的A纤维诱发反应。 C纤维诱发的反应不受影响。慢性MK801还阻止了脊髓中A纤维末端的正常结构重组。尽管C-纤维传入终末和背角中的细胞密度显然未受影响，但在经治疗的动物中并未发生表面突出的A-纤维初次传入产后更深层的撤回。与幼稚和媒介物处理的动物相比，脊柱MK801处理的动物对后足的机械刺激行为反射阈值也显着降低，而有害的热阈值不受影响。结果表明，脊髓内A纤维感觉连接的正常产后结构和功能发展是需要NMDA受体激活的活动依赖过程。

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