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首页> 外文期刊>The European Journal of Neuroscience >Stimulation of cortical acetylcholine release following blockade of ionotropic glutamate receptors in nucleus accumbens.
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Stimulation of cortical acetylcholine release following blockade of ionotropic glutamate receptors in nucleus accumbens.

机译：伏隔核中离子型谷氨酸受体受阻后刺激皮质乙酰胆碱释放。

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摘要

In vivo microdialysis techniques were used to determine the ability of glutamate receptors within the nucleus accumbens to trans-synaptically modulate the basal forebrain cortical cholinergic system. Rats were implanted with a dialysis probe in the medial prefrontal cortex to measure changes in cortical acetylcholine efflux and in the ipsilateral nucleus accumbens to locally manipulate glutamate receptor activity. Intra-accumbens perfusion of the broad spectrum ionotropic glutamate receptor antagonist kynurentate (1.0, 5.0 mm) led to a dose-dependent increase (maximum of 200%) in cortical acetylcholine efflux. This stimulated efflux was reproduced with the intra-accumbens perfusion of the AMPA/kainate antagonist DNQX (0.1, 0.25, 2.5 mm; maximum increase of 200%) or the NMDA antagonist D-CPP (10.0, 100.0, 200 micro M; maximum increase of 400%). These results reveal a significant glutamatergic tone within the accumbens of awake rats and support the hypothesis that accumbens efferents to basal forebrain modulate the excitability of the basal forebrain cortical cholinergic system.
机译：体内微透析技术用于确定伏隔核内谷氨酸受体反式突触调节基础前脑皮质胆碱能系统的能力。大鼠在内侧前额叶皮层植入了透析探针，以测量皮质乙酰胆碱外流和同侧伏隔核中的变化，以局部操纵谷氨酸受体的活性。广谱离子型谷氨酸受体拮抗剂犬菊酯（1.0，5.0 mm）的伏隔内灌注导致皮质乙酰胆碱外流剂量依赖性增加（最大200％）。通过AMPA /海藻酸盐拮抗剂DNQX（0.1，0.25，2.5 mm;最大增加200％）或NMDA拮抗剂D-CPP（10.0，100.0，200 micro M;最大增加）的腔内灌注来再现这种刺激的外流。 400％）。这些结果揭示了清醒大鼠伏隔内明显的谷氨酸能基调，并支持了伏隔内基脑传出物调节基前脑皮层胆碱能系统兴奋性的假说。

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