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首页> 外文期刊>The European Journal of Neuroscience >EphB receptors influence growth of ephrin-B1-positive statoacoustic nerve fibers.
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EphB receptors influence growth of ephrin-B1-positive statoacoustic nerve fibers.

机译：EphB受体会影响ephrin-B1阳性的静听神经纤维的生长。

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摘要

The Eph family of receptors and ligands has been implicated in a variety of developmental processes, including the provision of inhibitory guidance cues to developing nerve fibers. A unique property of the B class of receptors is that they are able to phosphorylate ephrin-B ligands, allowing for bi-directional, or reverse signalling. While most of the studies to date have focused on central nerve fibers, little is known about the role of Eph molecules in guiding nerve fibers of the peripheral nervous system. In the present study, ephrin-B1 was found to be highly expressed on developing peripheral nerve fibers including auditory and vestibular (statoacoustic) and dorsal root ganglion nerve fibers. In vitro assays revealed that EphB-Fc receptors inhibited further growth of statoacoustic nerve fibers. In contrast, EphA7-Fc and ephrin-B2-Fc did not prevent further growth of SAG. Together, these results suggest a role for EphB receptors in providing guidance signals to ephrin-B1-positive SAG nerve fibers.
机译：Eph受体和配体家族与多种发育过程有关，包括为发育中的神经纤维提供抑制性指导信号。 B类受体的独特属性是它们能够磷酸化ephrin-B配体，从而实现双向或反向信号传递。尽管迄今为止的大多数研究都集中在中枢神经纤维上，但关于Eph分子在引导周围神经系统的神经纤维中的作用知之甚少。在本研究中，发现ephrin-B1在发育中的周围神经纤维（包括听觉和前庭（静态）和背根神经节神经纤维）上高表达。体外测定表明，EphB-Fc受体抑制了静听神经纤维的进一步生长。相反，EphA7-Fc和ephrin-B2-Fc不能阻止SAG的进一步生长。在一起，这些结果表明EphB受体在向ephrin-B1阳性SAG神经纤维提供引导信号中的作用。

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