...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Contribution of amygdala neurons containing peptides and calcium-binding proteins to fear-potentiated startle and exploration-related anxiety in inbred Roman high- and low-avoidance rats.
【24h】

Contribution of amygdala neurons containing peptides and calcium-binding proteins to fear-potentiated startle and exploration-related anxiety in inbred Roman high- and low-avoidance rats.

机译：含有肽和钙结合蛋白的杏仁核神经元对近交罗马高避免回避大鼠恐惧增强的惊吓和探索相关焦虑的贡献。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The purpose of this study was to investigate amygdala-related fear and anxiety in two inbred rat lines differing in emotionality (RHA/Verh and RLA/Verh), and to relate the behaviour of the animals to neuronal types in different nuclei of the amygdala. The behavioural tests used were the motility test, elevated plus-maze and fear-potentiated startle response. The neurons investigated were immunoreactive for the anxiogenic peptide corticotropin-releasing factor (CRF-ir), the anxiolytic peptide neuropeptide Y (NPY-ir), and the calcium-binding proteins parvalbumin (PARV-ir) and calbindin (CALB-ir). The NPY-ir, PARV-ir and CALB-ir neurons studied were subpopulations of GABAergic neurons. RLA/Verh rats, which showed a significant fear-potentiation of the acoustic startle response, had more CRF-ir projection neurons in the central nucleus of the amygdala. The same RLA/Verh rats were either less or equally anxious in the motility test (similar to open field) and elevated plus-maze as compared with RHA/Verh rats. In accordance with this behaviour, the RLA/Verh rats had more NPY-ir neurons in the lateral, and more PARV-ir neurons in basal nuclei of the amygdala than RHA/Verh rats, but no differences were detected in the number of CRF-ir and CALB-ir neurons of the basolateral complex. In conclusion, the RLA/Verh rats displayed an opposite behaviour in the fear-potentiated startle model and the exploratory tests measuring anxiety based on choice behaviour. Thus, the anxiogenic systems in the central nucleus and anxiolytic systems in the basolateral complex of the amygdala might be differentially involved in the fear-potentiated startle paradigm and exploratory tests in the Roman rat lines.
机译：这项研究的目的是调查情绪不同的两个近交大鼠系（RHA / Verh和RLA / Verh）中杏仁核相关的恐惧和焦虑，并将动物的行为与杏仁核不同核中的神经元类型相关联。使用的行为测试是运动测试，高迷宫测试和恐惧增强的惊吓反应。研究的神经元对血管生成素促肾上腺皮质激素释放因子（CRF-ir），抗焦虑肽神经肽Y（NPY-ir）和钙结合蛋白小白蛋白（PARV-ir）和钙结合蛋白（CALB-ir）具有免疫反应性。所研究的NPY-ir，PARV-ir和CALB-ir神经元是GABA能神经元的亚群。 RLA / Verh大鼠表现出明显的恐惧惊吓反应，在杏仁核中央核中具有更多的CRF-ir投射神经元。与RHA / Verh大鼠相比，相同的RLA / Verh大鼠在运动测试中焦虑程度较低（或类似），且迷宫升高。根据这种行为，与RHA / Verh大鼠相比，RLA / Verh大鼠在外侧杏仁核中有更多的NPY-ir神经元，在杏仁核基底核中有更多的PARV-ir神经元，但是在CRF-基底外侧复合体的ir和CALB-ir神经元。总之，RLA / Verh大鼠在恐惧增强惊吓模型和基于选择行为测量焦虑的探索性试验中表现出相反的行为。因此，杏仁核中央核中的抗焦虑系统和基底外侧复合体中的抗焦虑系统可能在罗马大鼠品系中有差异地参与了恐惧增强的惊吓范式和探索性试验。

著录项

相似文献

  • 外文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号