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首页> 外文期刊>The European Journal of Neuroscience >Impaired spatial and sequential learning in rats treated neonatally with d-fenfluramine.
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Impaired spatial and sequential learning in rats treated neonatally with d-fenfluramine.

机译：新生儿用d-氟氟拉明治疗的大鼠的空间和顺序学习受损。

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d-Fenfluramine, a serotonin releaser, was administered to neonatal rats on postnatal days 11-20 (a stage of hippocampal development analogous to third trimester human ontogeny). As adults, the d-fenfluramine-treated offspring exhibited dose-related impairments of sequential and spatial learning and reference memory in the absence of sensorimotor impairments. Procedures to minimize stress and to control for other performance effects prior to testing for spatial learning demonstrated that nonspecific factors did not account for the selective effects of d-fenfluramine on learning and memory. Developmental d-fenfluramine-induced spatial and sequential learning deficits are similar to previous findings with developmental MDMA treatment. By contrast, recent findings with developmental d-methamphetamine treatment showed spatial learning deficits while sparing sequential learning. The spatial learning effects common to all three drugs suggest that they may share a common mechanism of action, however, the effects are not related to long-lasting changes in hippocampal 5-HT levels as no differences were found in adulthood. Whether the cognitive deficits are related to the effects of substituted amphetamines on corticosteroids, other aspects of the 5-HT system, or some unidentified neuronal substrates is not known, but the data demonstrate that these drugs are all capable of inducing long-term adverse effects on learning.
机译：在出生后的第11至20天（类似于第三代人的个体发育的海马体发育阶段）向新生大鼠施用d-氟氟拉明（5-羟色胺释放剂）。成年后，在没有感觉运动障碍的情况下，经d-芬氟拉明治疗的后代表现出与剂量有关的顺序和空间学习以及参考记忆障碍。在进行空间学习测试之前，将压力降至最低并控制其他性能影响的程序表明，非特异性因素并未说明d-氟氟拉明对学习和记忆的选择性作用。发育性d-芬氟拉明引起的空间和顺序学习缺陷与发育性MDMA治疗的先前发现相似。相比之下，发展性d-甲基苯丙胺治疗的最新发现显示出空间学习缺陷，同时保留了顺序学习。这三种药物共有的空间学习作用表明它们可能具有共同的作用机理，但是，这种作用与海马5-HT水平的长期变化无关，因为在成年期未发现差异。认知缺陷是否与取代的苯丙胺对皮质类固醇的作用，5-HT系统的其他方面或某些未知的神经元底物有关，但数据表明这些药物均具有诱发长期不良反应的能力。在学习上。

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