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首页> 外文期刊>The European Journal of Neuroscience >The neurosteroid allopregnanolone increases dopamine release and dopaminergic response to morphine in the rat nucleus accumbens.
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The neurosteroid allopregnanolone increases dopamine release and dopaminergic response to morphine in the rat nucleus accumbens.

机译：神经甾体阿洛培那那龙能增加伏隔核中多巴胺的释放和对吗啡的多巴胺能反应。

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摘要

Neurosteroids are a subclass of steroids that can be synthesized in the central nervous system independently from peripheral sources. Clinical studies in humans have associated these hormones with depression and postpartum mood disorders. In rodents, allopregnanolone (AlloP) has been shown to have anxiolytic and rewarding properties. These observations suggest that neurosteroids could interact with mood and motivation. However, the possible neural substrates of these effects remain unknown. In this report, we have studied the action of AlloP on the activity of the mesencephalic dopaminergic (DA) projection to the nucleus accumbens, which is considered one of the biological substrates of motivation and reward. This study was conducted by measuring extracellular concentrations of dopamine (DA) in the nucleus accumbens by means of microdialysis in freely moving rats. We studied both the direct effect of AlloP and the influence of this hormone on the DA response to an injection of morphine. AlloP dose-dependently increased the release of DA in the nucleus accumbens. Furthermore, this hormone doubled the DA response to morphine. These effects were observed for AlloP doses of 50 and 100 pmol injected intracerebroventricularly. These results suggest that the stimulatory effect of AlloP on DA could mediate some of the behavioural effects of neurosteroids and, in particular, the interaction of these hormones with mood and motivation.
机译：神经类固醇是类固醇的一个子类，可以在中枢神经系统中独立于外围来源进行合成。人体的临床研究已将这些激素与抑郁症和产后情绪障碍相关联。在啮齿动物中，已显示出Allopregnanolone（AlloP）具有抗焦虑和有益的特性。这些观察表明，神经固醇可能与情绪和动机相互作用。但是，这些作用的可能神经底物仍然未知。在本报告中，我们研究了AlloP对中脑多巴胺能（DA）投射到伏隔核的活动的作用，伏隔核被认为是动机和奖励的生物学底物之一。这项研究是通过在自由移动的大鼠中通过微透析测量伏隔核中细胞外多巴胺（DA）的浓度来进行的。我们研究了AlloP的直接作用以及该激素对注射吗啡的DA反应的影响。 AlloP剂量依赖性地增加伏隔核中DA的释放。此外，该激素使DA对吗啡的反应加倍。对于脑室内注射50和100 pmol的AlloP剂量，可以观察到这些效果。这些结果表明，AlloP对DA的刺激作用可以介导神经甾体的某些行为效应，尤其是这些激素与情绪和动机的相互作用。

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