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首页> 外文期刊>The European Journal of Neuroscience >Vagal motor neurons in rats respond to noxious and physiological gastrointestinal distention differentially.
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Vagal motor neurons in rats respond to noxious and physiological gastrointestinal distention differentially.

机译：大鼠迷走神经元对有害和生理性胃肠道扩张反应不同。

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Low-pressure gastrointestinal distention modulates gastrointestinal function by a vago-vagal reflex. Noxious visceral distention, as seen in an obstruction of the gastrointestinal tract, causes abdominal pain, vomiting and affective changes. Using single neuron recording and intracellular injection techniques, we characterized the neuronal responses of neurons in the dorsal motor nucleus of the vagus (DMNV) to low- and high-pressure distentions of stomach and duodenum. Low-pressure gastric distention inhibited the mean activity of the DMNV neurons whereas high-pressure gastric distention excited many neurons. Of 47 DMNV neurons, low-pressure gastric distention inhibited 39, excited four, and did not affect four neurons. High-pressure gastric distention inhibited 26, excited 20, and left one unaffected. Thirteen of the 39 DMNV neurons inhibited by low-pressure distention of the stomach reversed their response to excitation during high-pressure gastric distention. Among 47 DMNV neurons, low-pressure duodenal distention inhibited 30, excited 10, and did not affect the remaining seven neurons. High-pressure distention of the duodenum inhibited 25 and excited 22 neurons. Eight DMNV neurons inhibited by low-pressure duodenal distention were excited in early response to high-pressure distention of the duodenum. High-pressure duodenal distention caused an early excitation and late inhibition in the mean activity of the DMNV neurons while low-pressure duodenal distention only produced late inhibition. These results suggest that different reflexes are present between physiological distention and noxious stimulation of gastrointestinal tract.
机译：低压胃肠道扩张通过迷走神经反射来调节胃肠道功能。在胃肠道阻塞中可见有害的内脏膨胀会引起腹痛，呕吐和情感变化。使用单神经元记录和细胞内注射技术，我们表征了迷走神经背运动核（DMNV）中神经元对胃和十二指肠低压和高压膨胀的神经元反应。低压胃扩张会抑制DMNV神经元的平均活性，而高压胃扩张会激发许多神经元。在47个DMNV神经元中，低压胃扩张抑制了39个神经元，激发了四个神经元，并且没有影响四个神经元。高压胃扩张抑制了26，兴奋地抑制了20，而其中一个没有受到影响。胃低压扩张抑制的39个DMNV神经元中有13个在高压胃扩张期间逆转了其对兴奋的反应。在47个DMNV神经元中，低压十二指肠扩张抑制30个，兴奋10个，并且不影响其余七个神经元。十二指肠的高压扩张抑制了25个神经元并激发了22个神经元。在对十二指肠高压扩张的早期反应中，受到低压十二指肠扩张抑制的8个DMNV神经元被兴奋。高压十二指肠扩张导致DMNV神经元平均活动的早期兴奋和后期抑制，而低压十二指肠扩张仅产生后期抑制。这些结果表明生理膨胀和胃肠道有害刺激之间存在不同的反射。

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