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首页> 外文期刊>The European Journal of Neuroscience >Molecular phenotype of rat striatal neurons expressing the dopamine D5 receptor subtype.
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Molecular phenotype of rat striatal neurons expressing the dopamine D5 receptor subtype.

机译：表达多巴胺D5受体亚型的大鼠纹状体神经元的分子表型。

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摘要

Dopamine is one of the principal neurotransmitters in the basal ganglia, where it plays a critical role in motor control and cognitive function through its interactions with the specific dopamine receptors D1 to D5. Although the activities mediated by most dopamine receptor subtypes have already been determined, the role of the D5 receptor subtype in the basal ganglia has still not been established. Furthermore, it is often difficult to distinguish between dopamine D5 and D1 receptors as they are stimulated by the same ligands, and they have a similar molecular structure and pharmacology. In an effort to understand the differences between these two receptor subtypes, we have studied the distribution of neurons containing D5 receptors in the striatum, and their molecular phenotype. As a result, we show that the D5 receptor subtype is present in two different populations of striatal neurons, projection neurons and interneurons. Overall, the abundance of this receptor subtype in the striatum is low, particularly in striatal projection neurons of both the direct and indirect projection pathways. In contrast, the expression of D5 receptors in striatal interneurons (cholinergic, somatostatin- or parvalbumin-positive neurons) is high, while low to moderate expression was observed in calretinin-positive neurons. Our results demonstrate the presence of D5 receptors in all the striatal cell populations so far described, although at different intensities in each. The fact that a large number of striatal neurons express the D5 receptor subtype suggests that this receptor fulfils an important function in the process of integrating information in the striatum.
机译：多巴胺是基底神经节中的主要神经递质之一，在多巴胺中它通过与特定的多巴胺受体D1至D5相互作用而在运动控制和认知功能中发挥关键作用。尽管已经确定了大多数多巴胺受体亚型介导的活性，但仍未确定D5受体亚型在基底神经节中的作用。此外，由于多巴胺D5和D1受体被相同的配体刺激，并且具有相似的分子结构和药理作用，因此通常很难区分它们。为了理解这两种受体亚型之间的差异，我们研究了纹状体中含有D5受体的神经元的分布及其分子表型。结果，我们表明D5受体亚型存在于两个不同的纹状体神经元，投射神经元和中间神经元群体中。总体而言，纹状体中该受体亚型的丰度较低，尤其是在直接和间接投射途径的纹状体投射神经元中。相反，在纹状体中间神经元（胆碱能，生长抑素或小白蛋白阳性神经元）中D5受体的表达较高，而在钙调蛋白阳性神经元中则观察到低至中等的表达。我们的结果表明，到目前为止，所有纹状体细胞群体中都存在D5受体，尽管每种中的强度不同。大量纹状体神经元表达D5受体亚型的事实表明，该受体在纹状体中整合信息的过程中起着重要的作用。

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