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首页> 外文期刊>The European Journal of Neuroscience >Cerebellar LTD facilitates but is not essential for long-term adaptation of the vestibulo-ocular reflex.
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Cerebellar LTD facilitates but is not essential for long-term adaptation of the vestibulo-ocular reflex.

机译：小脑LTD有助于长期适应前庭眼反射，但并非必不可少。

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摘要

The induction of cerebellar long-term depression (LTD) at the parallel fibre-Purkinje cell synapse is selectively blocked in L7-PKCi transgenic mice, rendering these mice unable to adaptively modify their vestibulo-ocular reflex (VOR) during visuo-vestibular training for a few hours. Despite this deficit, their eye movement performance as well as their general motor behaviour appears unaffected. This combination suggests that, in the long term, residual forms of plasticity in the vestibulo-cerebellar circuitry can compensate for the absence of cerebellar LTD. To investigate whether LTD-deficient mice exhibit motor learning in the long run, we subjected L7-PKCi transgenic mice to visuo-vestibular training paradigms that were aimed at either increasing or decreasing the VOR response in the course of eight consecutive days. During the increasing paradigm, the VOR gain of transgenic mice increased significantly, while VOR gain decreased and VOR phase-lead increased during the decreasing paradigm. The impact of these long training periods on the VOR was significantly smaller in LTD-deficient mice than in wild type littermates. Thus, while LTD may be necessary for short-term VOR adaptation, it facilitates but is not required for long-term adaptation of the VOR.
机译：在L7-PKCi转基因小鼠中，平行纤维-Purkinje细胞突触对小脑长期抑郁症（LTD）的诱导被选择性阻滞，致使这些小鼠在视觉-前庭训练期间无法适应性地修改其前庭眼反射（VOR）几个小时。尽管存在这种缺陷，但它们的眼动表现以及一般的运动行为似乎并未受到影响。这种结合表明，从长远来看，前庭小脑回路中的可塑性残余形式可以弥补小脑LTD的缺失。为了研究LTD缺陷型小鼠长期是否表现出运动学习，我们对L7-PKCi转基因小鼠进行了视觉-前庭训练范例，旨在在连续八天的过程中增加或减少VOR反应。在增加范式期间，转基因小鼠的VOR增益显着增加，而在减少范式期间，VOR增益降低而VOR相位超前。与野生型同窝仔相比，LTD缺陷型小鼠的这些长时间训练对VOR的影响要小得多。因此，尽管LTD对于短期VOR适应可能是必需的，但它有助于VOR的长期适应，但不是必需的。

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