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首页> 外文期刊>The European Journal of Neuroscience >Time course of motor cortex reorganization following botulinum toxin injection into the vibrissal pad of the adult rat.
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Time course of motor cortex reorganization following botulinum toxin injection into the vibrissal pad of the adult rat.

机译：肉毒杆菌毒素注入成年大鼠的震颤垫后运动皮层重组的时间过程。

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The present experiment studies representation patterns in the motor cortex (M1) of adult rats, 1, 3, 6, and 12 days after unilateral injection of Botulinum Toxin (BTX) into the vibrissa pad. Intracortical microstimulation (ICMS) was used to evidence changes in the representation over time and in the current thresholds required to evoke movements inside the disconnected vibrissa region. After 1 day, isolated as well as contiguous negative sites were observed within the motor cortex corresponding to the disconnected vibrissa region. Thereafter the percentage of unresponsive sites decreased so that after 6 days, the number of unresponsive sites was not significantly higher than those in the control hemispheres. Within the disconnected vibrissa region, electrical stimulation elicited forelimb, eye, ipsilateral vibrissa and neck movements. Following BTX injection, the enlargement of the forelimb representation into the disconnected vibrissa representation began during the first day and stabilized during the second week after injection. In the first days, stimulation thresholds in expanded forelimb sites were higher than those required for similar movement in normal M1 forelimb representation. These thresholds then declined so that in approximately 6 days they were similar to normal. There was no clear evidence that stimulation of sites in the medial part of disconnected vibrissa-cortex evoked eye movements during the first 6 days after BTX injection. After this time, thresholds required to evoke eye movement in expanded sites were generally similar to, and never higher than, those needed to evoke this movement in control sites. Intermingled ipsilateral vibrissa and neck movement occupies part of the medial vibrissa region. Over the 12 days, extension of the ipsilateral vibrissa representation shrank while the representation of neck movement remained unchanged. Throughout the entire time there was no change in the excitability of these sites and the thresholds remained higher than that needed to elicit the vibrissa movement normally represented in this cortical region. No significant differences in threshold were found over time for any of the other movement categories represented in M1. These results indicate that, over time, the new movements inside the disconnected vibrissa region develop differently in M1 following peripheral motor disconnection. The implications for mechanisms involved in cortical plasticity are discussed.
机译：本实验研究成年大鼠运动皮层（M1）在单侧注射肉毒杆菌毒素（BTX）到触须垫中后1、3、6和12天的表示模式。皮层内微刺激（ICMS）用于证明表示随时间的变化以及引起断开的触须区域内运动所需的当前阈值。 1天后，在运动皮层内观察到与断开的触须区域相对应的孤立的和连续的负位点。此后，无反应位点的百分比降低，因此6天后，无反应位点的数量不会显着高于对照半球中的位点。在断开的触须区域内，电刺激引起前肢，眼睛，同侧触须和颈部运动。 BTX注射后，前肢增大到断开的触须表示开始于注射后的第一天，并在注射后第二周稳定下来。在最初的几天中，扩展前肢部位的刺激阈值高于正常M1前肢表示中类似运动所需的阈值。然后，这些阈值下降，因此在大约6天内，它们与正常水平相似。没有明确的证据表明，在注射BTX后的前6天中，断开的触须皮层内侧部分的刺激会引起眼球运动。在这段时间之后，在扩展位置引起眼睛运动所需的阈值通常与在控制位置引起眼睛运动所需的阈值相似，但从未高于此阈值。混杂的同侧触颤和颈部运动占据了内侧触颤区域的一部分。在过去的12天中，同侧触痛的表现缩小，而颈部运动的表现保持不变。在整个过程中，这些部位的兴奋性没有变化，并且阈值仍然高于引发该皮质区域通常表现出的触滑运动所需的阈值。对于M1中代表的任何其他运动类别，阈值随时间的变化均无显着差异。这些结果表明，随着时间的流逝，外围电机断开后，断开的触角区域内部的新运动在M1中的发展不同。讨论了涉及皮层可塑性的机制的含义。

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