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首页> 外文期刊>The European Journal of Neuroscience >Light-adaptive effects of retinoic acid on receptive field properties of retinal horizontal cells.
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Light-adaptive effects of retinoic acid on receptive field properties of retinal horizontal cells.

机译：视黄酸对视网膜水平细胞感受野特性的光适应作用。

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摘要

Besides its role in ocular development, retinoic acid (RA), which is a light-correlated byproduct of the phototransduction cycle, was recently shown to affect light-driven synaptic plasticity in the outer plexiform layer of the adult fish retina. Tuning by ambient light conditions of the retinal network properties is very prominent in outer plexiform layer circuits, and we therefore examined whether RA could affect cone horizontal cell physiology similar to ambient light. Performing intracellular recordings and dye injections in the dark-adapted inverted eyecup preparation of the carp, we found that RA reduced the receptive fields of horizontal cell somata and impaired gap junctional communication. This action was not observed among coupled axon terminals of horizontal cells and appeared to be stereospecific because it could only be attributed to all-trans and 13-cis RA but not to the 9-cis isomer and photoisomerized all-trans RA. Modulation of receptive field size occurred independently of the dopaminergic system. Furthermore, RA affected the light responsiveness of cone horizontal cells. Compared to the dark-adapted condition, responsiveness to intense light stimulation was enhanced but decreased when low intensities were used. Moreover, following RA treatment H2-type horizontal cells of dark-adapted retinae which do not give rise to colour-opponent light properties became colour-opponent and performed depolarizing responses to long-wavelength stimulation. In all these cases RA perfectly matched the effects of light adaptation, supporting the notion that RA acts as an endogenous neuromodulator.
机译：除了其在眼部发育中的作用外，最近还发现视黄酸（RA）是光转导周期的光相关副产物，它会影响成鱼视网膜外丛状层中光驱动的突触可塑性。在外部丛状层电路中，通过环境光条件调节视网膜网络特性非常重要，因此我们检查了RA是否会像环境光一样影响视锥细胞水平的细胞生理。在暗适应的鲤鱼倒立眼罩制备物中进行细胞内记录和染料注射，我们发现RA减少了水平细胞体的接受野并削弱了间隙连接通讯。在水平细胞的耦合轴突末端之间未观察到该作用，并且似乎是立体特异性的，因为它只能归因于全反式和13-顺式RA，而不能归因于9-顺式异构体和光异构化的全反式RA。受体场大小的调节独立于多巴胺能系统而发生。此外，RA影响锥体水平细胞的光响应性。与暗适应条件相比，当使用低强度时，对强光刺激的响应性增强但下降。而且，在RA处理之后，不产生颜色相反的光特性的暗适应的视网膜的H2型水平细胞变成了颜色相反的并且对长波长刺激执行去极化响应。在所有这些情况下，RA都与光适应效果完全匹配，从而支持了RA充当内源性神经调节剂的观点。

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