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首页> 外文期刊>The European Journal of Neuroscience >Chronic levodopa therapy does not improve skilled reach accuracy or reach range on a pasta matrix reaching task in 6-OHDA dopamine-depleted (hemi-Parkinson analogue) rats.
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Chronic levodopa therapy does not improve skilled reach accuracy or reach range on a pasta matrix reaching task in 6-OHDA dopamine-depleted (hemi-Parkinson analogue) rats.

机译：长期左旋多巴疗法不能改善6-OHDA多巴胺贫乏（hemi-Parkinson类似物）大鼠的意大利面食达到面食任务的准确度或范围。

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L-dopa therapy reverses some but not all of the motor deficits in human Parkinson patients. Although a number rat analogues of human Parkinson's disease have been developed for evaluating the efficacy of drug therapies, it is not known whether L-dopa has a similar selective action on the motor symptoms in the rat models. To examine the effectiveness of L-dopa in reversing the motor deficits in rats, we administered 6-OHDA unilaterally to produce hemi-Parkinson rats, which were then trained to reach for food using either their impaired (contralateral to the lesion) limb or their good (ipsilateral to the lesion) limb. To assess the skill, accuracy and range of limb movement, rats reached for pasta from a horizontal array of 260 vertically orientated pieces of pasta. The number and location of pasta pieces taken from this matrix was calculated and the qualitative aspects of the reaching movements were rated. The quantitative data on pasta sticks retrieved indicated that forelimb extension and movement radius around the shoulder joint was reduced by 6-OHDA treatment and did not improve after chronic L-dopa treatment. The qualitative analysis showed that grasping patterns, paw movements and body movements impaired by the lesion were also not improved by L-dopa treatment. These findings are the first in the rat to suggest that whereas L-dopa has a general activating effect on the rat's whole-body movements, as displayed in contralateral rotation, its effectiveness does not extend to skilled forelimb movements. The results are discussed in relationship to the idea that the restoration of some skilled movements may require normal synaptic function.
机译：左旋多巴疗法可逆转帕金森病患者的部分但并非全部运动障碍。尽管已经开发了许多人类帕金森氏病的大鼠类似物来评估药物治疗的功效，但尚不清楚L-多巴是否对大鼠模型中的运动症状具有类似的选择性作用。为了检查左旋多巴在逆转大鼠运动功能障碍中的有效性，我们单方面施用了6-OHDA来生产半帕金森大鼠，然后训练它们使用受损的（患侧对侧）肢体或患肢好（患侧）。为了评估肢体运动的技巧，准确性和范围，大鼠从水平排列的260个垂直定向的面食的水平阵列中获取了面食。计算从该矩阵中获取的面食块的数量和位置，并对到达动作的定性方面进行评估。检索到的意大利面棍的定量数据表明，6-OHDA处理降低了前肢伸展和肩关节周围的运动半径，而慢性左旋多巴治疗后并没有改善。定性分析表明，左旋多巴治疗也不能改善病变所致的抓握方式，爪子运动和身体运动。这些发现是首次在大鼠中表明，尽管左旋多巴对大鼠的全身运动具有一般的激活作用（如对侧旋转所示），但其有效性并未扩展到熟练的前肢运动。讨论结果与某些技能动作的恢复可能需要正常的突触功能有关。

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