...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Role of adrenal medulla in development of sexual dimorphism in inflammation.
【24h】

Role of adrenal medulla in development of sexual dimorphism in inflammation.

机译：肾上腺髓质在炎症性二态性发展中的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Many inflammatory diseases show a female predilection in adults, but not prepubertally. Because sex differences in the inflammatory response in the adult rat are mediated, in part, by sexual dimorphism in adrenal medullary function, we investigated the contribution of the adrenal medulla to the ontogeny of sexual dimorphism in inflammation. Whilst there was no sex difference in the magnitude of the plasma extravasation (PE) induced by the potent inflammatory mediator bradykinin (BK) in prepubertal rats, in adult rats BK-induced PE was markedly greater in males. Also, adult male rats, gonadectomized prior to puberty, had a lower magnitude of BK-induced PE than did adult male controls, whilst adult females gonadectomized prepubertally had higher BK-induced PE than did controls. In rats gonadectomized after puberty, the magnitude of BK-induced PE in adult males was not affected, whilst in females it resulted in significantly higher BK-induced PE, similar to the effect of prepubertal gonadectomy. When tested prepubertally, adrenal denervation increased the magnitude of BK-induced PE in females, but not in males. In contrast, in both males and females tested as adults, but castrated prepubertally, and in gonad-intact adult females, adrenal denervation significantly increased the magnitude of BK-induced PE. Adrenal denervation in prepubertal females given adult levels of 17beta-oestradiol produced a marked enhancement in the denervation-induced increase in magnitude of BK-induced PE compared to females not exposed prematurely to sex hormones. These studies suggest that an adrenal medulla-dependent inhibition of BK-induced PE is present in female but not male rats, and is enhanced by oestrogen but suppressed by testosterone.
机译：许多炎症性疾病在成年女性中表现出女性偏爱，但在青春期前却没有。因为成年大鼠炎症反应中的性别差异部分是由肾上腺髓质功能性二态性介导的，所以我们研究了肾上腺髓质对炎症中性二态性的存在的贡献。尽管在青春期前大鼠中强效炎性介质缓激肽（BK）诱导的血浆外渗（PE）幅度没有性别差异，但在成年大鼠中，雄性BK诱导的PE明显更大。同样，在青春期前接受腺体切除的成年雄性大鼠比成年雄性对照具有较低的BK诱导的PE，而在青春期前经性腺切除的成年雌性则具有高于BK诱导的PE。在青春期后进行性腺切除的大鼠中，成年雄性的BK诱导的PE的大小不受影响，而雌性中的BK诱导的PE则明显更高，类似于青春期前性腺切除术的效果。在青春期前进行测试时，女性的肾上腺去神经增加了BK诱导的PE的强度，而男性则没有。相比之下，在成年男性和女性中，但在青春期前去势，以及在性腺完整的成年女性中，肾上腺去神经支配显着增加了BK诱导的PE的强度。与未过早暴露于性激素的女性相比，给定成人17β-雌二醇水平的青春期前女性的肾上腺神经支配产生了明显的增强。这些研究表明，雌性大鼠而非雄性大鼠存在肾上腺髓质依赖性的BK诱导的PE抑制作用，雌激素可增强这种抑制作用，而睾丸激素则可抑制这种作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号