...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Neuroprotective effect of propofol against excitotoxic injury to locomotor networks of the rat spinal cord invitro
【24h】

Neuroprotective effect of propofol against excitotoxic injury to locomotor networks of the rat spinal cord invitro

机译：异丙酚对大鼠脊髓运动网络兴奋性毒性损伤的神经保护作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although neuroprotection to contain the initial damage of spinal cord injury (SCI) is difficult, multicentre studies show that early neurosurgery under general anaesthesia confers positive benefits. An interesting hypothesis is that the general anaesthetic itself might largely contribute to neuroprotection, although invivo clinical settings hamper studying this possibility directly. To further test neuroprotective effects of a widely used general anaesthetic, we studied if propofol could change the outcome of a rat isolated spinal cord SCI model involving excitotoxicity evoked by 1h application of kainate with delayed consequences on neurons and locomotor network activity. Propofol (5m; 4-8h) enhanced responses to GABA and depressed those to NMDA together with decrease in polysynaptic reflexes that partly recovered after 1day washout. Fictive locomotion induced by dorsal root stimuli or NMDA and serotonin was weaker the day after propofol application. Kainate elicited a significant loss of spinal neurons, especially motoneurons, whose number was halved. When propofol was applied for 4-8h after kainate washout, strong neuroprotection was observed in all spinal areas, including attenuation of motoneuron loss. Although propofol had minimal impact on recovery of electrophysiological characteristics 24h later, it did not further depress network activity. A significant improvement in disinhibited burst periodicity suggested potential to ameliorate neuronal excitability in analogy to histological data. Functional recovery of locomotor networks perhaps required longer time due to the combined action of excitotoxicity and anaesthetic depression at 24h. These results suggest propofol could confer good neuroprotection to spinal circuits during experimental SCI.
机译：尽管很难通过神经保护作用来抑制脊髓损伤（SCI）的初始损伤，但多中心研究表明，全身麻醉下的早期神经外科手术具有积极的益处。一个有趣的假设是，尽管体内临床环境阻碍了直接研究这种可能性，但全身麻醉剂本身可能在很大程度上有助于神经保护作用。为了进一步测试广泛使用的全身麻醉剂的神经保护作用，我们研究了异丙酚是否可以改变大鼠分离的脊髓SCI模型的结果，该模型涉及因施加海藻酸盐1h而引起的兴奋性毒性，对神经元和运动网络活动具有延迟性后果。丙泊酚（5m; 4-8h）增强了对GABA的反应，并降低了对NMDA的反应，同时多突触反射减少，冲洗1天后部分恢复。异丙酚应用后第二天，由背根刺激或NMDA和5-羟色胺引起的虚构运动较弱。海藻酸盐引起脊髓神经元的大量损失，尤其是运动神经元，其数量减少了一半。海藻酸盐冲刷后应用异丙酚4-8h，在所有脊髓区域均观察到强烈的神经保护作用，包括运动神经元丢失的减弱。尽管异丙酚在24小时后对电生理特性的恢复影响很小，但它并未进一步抑制网络活动。与组织学数据类似，在抑制性猝发周期性方面的显着改善表明可能改善神经元兴奋性。运动神经网络的功能恢复可能需要更长的时间，这是由于24h的兴奋性毒性和麻醉药抑制作用共同作用。这些结果表明，丙泊酚可以在实验性脊髓损伤期间为脊髓回路提供良好的神经保护作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号