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首页> 外文期刊>The European Journal of Neuroscience >Differential effects of hunger and satiety on insular cortex and hypothalamic functional connectivity
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Differential effects of hunger and satiety on insular cortex and hypothalamic functional connectivity

机译：饥饿和饱腹感对岛状皮质和下丘脑功能连接的不同影响

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The insula cortex and hypothalamus are implicated in eating behaviour, and contain receptor sites for peptides and hormones controlling energy balance. The insula encompasses multi-functional subregions, which display differential anatomical and functional connectivities with the rest of the brain. This study aimed to analyse the effect of fasting and satiation on the functional connectivity profiles of left and right anterior, middle, and posterior insula, and left and right hypothalamus. It was hypothesized that the profiles would be altered alongside changes in homeostatic energy balance. Nineteen healthy participants underwent two 7-min resting state functional magnetic resonance imaging scans, one when fasted and one when satiated. Functional connectivity between the left posterior insula and cerebellum/superior frontal gyrus, and between left hypothalamus and inferior frontal gyrus was stronger during fasting. Functional connectivity between the right middle insula and default mode structures (left and right posterior parietal cortex, cingulate cortex), and between right hypothalamus and superior parietal cortex was stronger during satiation. Differences in blood glucose levels between the scans accounted for several of the altered functional connectivities. The insula and hypothalamus appear to form a homeostatic energy balance network related to cognitive control of eating; prompting eating and preventing overeating when energy is depleted, and ending feeding or transferring attention away from food upon satiation. This study provides evidence of a lateralized dissociation of neural responses to energy modulations.
机译：岛叶皮质和下丘脑与饮食行为有关，并且含有控制能量平衡的肽和激素的受体位点。绝缘体包含多功能子区域，这些子区域与大脑的其余部分显示出不同的解剖学和功能连接性。这项研究旨在分析禁食和饱食对左，右前，中和后岛以及左下丘脑和右下丘脑功能连接的影响。假设轮廓将随着稳态能量平衡的变化而改变。 19名健康参与者进行了两次7分钟的静息状态功能磁共振成像扫描，一次禁食，一次饱腹。禁食期间，左后岛与小脑/上额回之间以及左下丘脑和额下回之间的功能连接更强。饱食期间，右中岛和默认模式结构（左右后顶叶皮层，扣带回皮层）之间以及右下丘脑和顶叶上皮层之间的功能连接性更强。两次扫描之间的血糖水平差异是造成功能连接性改变的原因。岛突和下丘脑似乎形成了与饮食的认知控制有关的体内平衡能量平衡网络。提醒您进食并防止能量耗尽时暴饮暴食，并在饱食时停止进食或将注意力从食物转移开。这项研究提供了神经反应对能量调制的侧向解离的证据。

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