...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >High-frequency stimulation of the subthalamic nucleus modulates neuronal activity in the lateral habenula nucleus
【24h】

High-frequency stimulation of the subthalamic nucleus modulates neuronal activity in the lateral habenula nucleus

机译：丘脑下核的高频刺激调节外侧ha核的神经元活动

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is often used to treat movement disability in advanced Parkinson's disease, but some patients experience debilitating psychiatric effects including depression. Interestingly, HFS of the STN modulates 5-HT neurons in the dorsal raphe nucleus (DRN) which are linked to depression, but the neural substrate of this effect is unknown. Here, we tested the effect of STN stimulation on neuronal activity in the lateral habenula nucleus (LHb), an important source of input to DRN 5-HT neurons and also a key controller of emotive behaviours. LHb neurons were monitored in anaesthetized rats using single-unit extracellular recording, and localization within the LHb was confirmed by juxtacellular labelling. HFS of the STN (130Hz) evoked rapid changes in the firing rate of the majority of LHb neurons tested (38 of 68). Some LHb neurons (19/68) were activated by HFS, while others (19/68), distinguished by a higher basal firing rate, were inhibited. LHb neurons that project to the DRN were identified using antidromic activation and collision testing (n=17 neurons). Some of these neurons (5/17) were also excited by HFS of the STN, and others (7/17) were inhibited although this was only a statistical trend. In summary, HFS of the STN modulated the firing of LHb neurons, including those projecting to the DRN. The data identify that the STN impacts on the LHb-DRN pathway. Moreover, this pathway may be part of the circuitry mediating the psychiatric effects of STN stimulation experienced by patients with Parkinson's disease.
机译：丘脑底核（STN）的高频刺激（HFS）通常用于治疗晚期帕金森氏病的运动障碍，但有些患者会出现使人沮丧的精神疾病，包括抑郁症。有趣的是，STN的HFS调节背沟核（DRN）中与抑郁症相关的5-HT神经元，但这种作用的神经底物尚不清楚。在这里，我们测试了STN刺激对外侧ha核（LHb）中神经元活动的影响，后者是DRN 5-HT神经元输入的重要来源，也是情绪行为的关键控制者。使用单单元细胞外记录法在麻醉的大鼠中监测LHb神经元，并通过近细胞标记确认LHb内的定位。 STN的HFS（130Hz）引起了测试的大多数LHb神经元放电速率的快速变化（68中的38）。一些LHb神经元（19/68）被HFS激活，而其他（19/68）被较高的基础放电率所抑制。使用抗drodromic激活和碰撞测试确定了投射到DRN的LHb神经元（n = 17个神经元）。尽管这只是统计趋势，但其中一些神经元（5/17）也被STN的HFS兴奋，而其他神经元（7/17）被抑制。总之，STN的HFS调节LHb神经元的放电，包括投射到DRN的神经元。数据表明STN影响LHb-DRN途径。此外，该途径可能是介导帕金森氏病患者所经历的STN刺激的精神病效应的电路的一部分。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号