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首页> 外文期刊>The European Journal of Neuroscience >The ventromedial hypothalamus mediates predator fear memory
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The ventromedial hypothalamus mediates predator fear memory

机译：下腹丘脑腹膜介导捕食者恐惧记忆

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The amygdala has been shown to be essential for the processing of acute and learned fear across animal species. However, the downstream neural circuits that mediate these fear responses differ according to the nature of the threat, with separate pathways having been identified for predator, conspecific and physically harmful threats. In particular, the dorsomedial part of the ventromedial hypothalamus (VHMdm) is critical for the expression of defensive responses to predators. Here, we tested the hypothesis that this circuit also participates in predator fear memory by transient pharmacogenetic inhibition of the VMHdm and its downstream effector, the dorsal periaqueductal grey, during predator fear learning in the mouse. Our data demonstrate that neural activity in the VMHdm is required for both the acquisition and recall of predator fear memory, whereas that of its downstream effector, the dorsal periaqueductal grey, is required only for the acute expression of fear. These findings are consistent with a role for the medial hypothalamus in encoding an internal emotional state of fear.
机译：杏仁核已被证明对处理跨动物物种的急性恐惧和学习恐惧至关重要。然而，介导这些恐惧反应的下游神经回路根据威胁的性质而有所不同，已经为掠食性，同种性和身体有害威胁确定了单独的途径。特别是，腹侧下丘脑（VHMdm）的背部部分对于表达对食肉动物的防御反应至关重要。在这里，我们测试了以下假设：在老鼠进行捕食者恐惧学习期间，该电路还通过对VMHdm及其下游效应子背侧导水管灰色的瞬时药理学抑制作用而参与了捕食者恐惧记忆。我们的数据表明，VMHdm中的神经活动既是捕食者恐惧记忆的获取和回忆所必需的，而其下游效应器背周导水管的灰色神经活动仅是恐惧的急性表达所必需的。这些发现与内侧下丘脑在编码恐惧的内部情绪状态中的作用一致。

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