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首页> 外文期刊>The European Journal of Neuroscience >Glial cell line-derived neurotrophic factor in genetically defined fear-induced aggression
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Glial cell line-derived neurotrophic factor in genetically defined fear-induced aggression

机译：胶质细胞系衍生的神经营养因子在遗传定义的恐惧诱导的侵略中

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Glial cell line-derived neurotrophic factor (GDNF) plays an important role in maintenance of neuronal system throughout life. However, there is a lack of data on the involvement of GDNF in the regulation of different kinds of behavior. In this study, GDNF, its precursor (proGDNF) and GDNF mRNA levels were investigated in the brain of rats selectively bred for 85 generations for either high level or for the lack of affective aggressiveness toward human. It was found that GDNF mRNA level was decreased in the frontal cortex, increased in the raphe nuclei area of the midbrain of aggressive rats compared to tame animals and was not detected in the amygdala and hypothalamus. The level of proGDNF was reduced in the raphe nuclei area of the midbrain of highly aggressive rats and was not detected in the striatum, nucleus accumbens of investigated animals. Two forms of mature GDNF - monomer and dimer - were revealed. GDNF monomer level was increased in the raphe nuclei area, substantia nigra and amygdala of aggressive rats and it was not found in the frontal cortex and nucleus accumbens of investigated rats. Dimer GDNF level was found in all investigated brain structures. It was reduced in the hippocampus and increased in amygdala of highly aggressive rats. Thus, considerable structure-specific differences in GDNF expression between highly aggressive and nonaggressive rats were shown. The data suggested the implication of both mature GDNF monomer and dimer as well as proGDNF in the mechanism underlying genetically defined aggressiveness.
机译：胶质细胞源性神经营养因子（GDNF）在整个生命的神经系统维持中起着重要作用。但是，缺乏有关GDNF参与调节各种行为的数据。在这项研究中，研究了GDNF，其前体（proGDNF）和GDNF mRNA水平在高选择性或缺乏对人类的情感侵略性的情况下选择性繁殖了85代的大鼠的大脑。已发现，与驯服动物相比，侵略性大鼠的额叶皮质中GDNF mRNA水平降低，在中脑的沟纹核区域中升高，而在杏仁核和下丘脑中未检测到。在高度侵袭性大鼠的中脑的裂纹核区域中，proGDNF的水平降低，而在被调查动物的纹状体，伏隔核中未检测到。揭示了两种形式的成熟GDNF-单体和二聚体。攻击性大鼠的缝核区，黑质和杏仁核中的GDNF单体水平升高，而在所研究大鼠的额叶皮层和伏隔核中未发现GDNF单体水平升高。在所有研究的大脑结构中均发现二聚体GDNF水平。在高度侵袭性大鼠中，其在海马中减少并且在杏仁核中增加。因此，在高度攻击性和非攻击性大鼠之间的GDNF表达中显示出相当大的结构特异性差异。数据表明，成熟的GDNF单体和二聚体以及proGDNF都可能在遗传定义的侵略性机制中起作用。

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