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首页> 外文期刊>The European Journal of Neuroscience >Fear memory retrieval induces CREB phosphorylation and Fos expression within the amygdala.
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Fear memory retrieval induces CREB phosphorylation and Fos expression within the amygdala.

机译：恐惧记忆恢复在杏仁核内诱导CREB磷酸化和Fos表达。

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Fear memory retrieval has been shown to induce a protein-synthesis dependent re-consolidation of memories within the amygdala. Here, using immunocytochemistry, we investigated the molecular basis of this process in the rat and show that retrieval of a cued fear memory induces the activation, by phosphorylation, of the transcription factor CREB within the basal and lateral nuclei of the amygdala, as well as expression of the CREB-regulated immediate-early gene, c-fos, in the basal amygdala. We also show an increase in CREB phosphorylation within the central nucleus of the amygdala following behavioural testing, with an accompanying increase in Fos-immunoreactive nuclei in animals retrieving the cued association. There were no changes in either phosphorylated CREB or Fos in the hippocampus following exposure to discrete fear stimuli. These results show that activation of CREB, which has been shown to be involved in the formation of long-term fear memories, also accompanies memory retrieval, and also suggest a role for CREB phosphorylation in memory re-consolidation following retrieval.
机译：恐惧记忆的恢复已经显示出可以诱导杏仁核内记忆的蛋白质合成依赖性重新整合。在这里，我们使用免疫细胞化学研究了这一过程在大鼠中的分子基础，并表明对线索恐惧恐惧记忆的检索通过杏仁核基核和外侧核内的转录因子CREB的磷酸化诱导激活。 CREB调节的立即早期基因c-fos在基底杏仁核中的表达我们还显示，行为测试后杏仁核中央核内CREB磷酸化的增加，伴随着动物中提示Fos免疫反应性核的增加。暴露于离散的恐惧刺激后，海马中的磷酸化CREB或Fos没有变化。这些结果表明，CREB的激活与长期的恐惧记忆的形成有关，CREB的激活也伴随着记忆的恢复，并且还暗示了CREB磷酸化在恢复后的记忆重建中的作用。

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