...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Forced swimming triggers vasopressin release within the amygdala to modulate stress-coping strategies in rats.
【24h】

Forced swimming triggers vasopressin release within the amygdala to modulate stress-coping strategies in rats.

机译：强迫游泳会触发杏仁核内血管加压素的释放，从而调节大鼠的应激应对策略。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Previously, we have demonstrated that forced swimming triggers the release of arginine vasopressin (AVP) within the septum of rats, where AVP modulates stress-coping strategies. The present study was designed to examine the effects of forced swimming on the release of AVP within the amygdala. Therefore, adult male Wistar rats were chronically implanted with a microdialysis probe aimed at the amygdala to monitor the local release of AVP under both resting and stress conditions. A 10-min forced swimming session caused a significant increase in the extracellular AVP concentration (to 366 +/- 90% of baseline; P < 0.05) within this brain area. In a subsequent experiment we investigated the physiological impact of the stressor-induced release of AVP by administrating the AVP V1 receptor antagonist d(CH2)5Tyr(Me)AVP into the amygdala via inverse microdialysis. Bilateral antagonist treatment modulated the behavioural response acutely by increasing the time the animals spent struggling and by reducing the time the animals floated. Our results demonstrate a significant activation of the vasopressinergic system within the amygdala in response to forced swimming. AVP released within the amygdala seems to be involved in the generation of passive coping strategies in stressful situations. Taken together with previous findings the results of the present study suggest that AVP is released within septum and amygdala to balance the behavioural response during forced swimming.
机译：以前，我们已经证明，强迫游泳会触发大鼠中隔内精氨酸加压素（AVP）的释放，其中AVP调节应激应对策略。本研究旨在检查强迫游泳对杏仁核内AVP释放的影响。因此，成年雄性Wistar大鼠被长期植入针对杏仁核的微透析探针，以监测静止和压力条件下AVP的局部释放。强迫游泳10分钟会导致此脑区域内细胞外AVP浓度显着增加（达到基线的366 +/- 90％; P <0.05）。在随后的实验中，我们通过逆向微透析将AVP V1受体拮抗剂d（CH2）5Tyr（Me）AVP给药至杏仁核，从而研究了应激诱导的AVP释放的生理影响。双边拮抗剂治疗通过增加动物挣扎的时间和减少动物漂浮的时间来急性调节行为反应。我们的结果表明杏仁核内的血管加压素系统对强迫游泳有明显的激活作用。杏仁核内释放的AVP似乎参与了压力情况下的被动应对策略的产生。结合以前的发现，本研究的结果表明AVP在隔垫和杏仁核内释放，以平衡强迫游泳过程中的行为反应。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号