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首页> 外文期刊>The European Journal of Neuroscience >Substantia nigra pars reticulata neurons code initiation of a serial pattern: implications for natural action sequences and sequential disorders.
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Substantia nigra pars reticulata neurons code initiation of a serial pattern: implications for natural action sequences and sequential disorders.

机译：黑质黑质网状神经元编码序列模式的启动：对自然作用序列和顺序性疾病的影响。

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摘要

Sequences of movements are initiated abnormally in neurological disorders involving basal ganglia dysfunction, such as Parkinson's disease or Tourette's syndrome. The substantia nigra pars reticulata (SNpr) is one of the two primary output structures of the basal ganglia. However, little is known about how substantia nigra mediates the initiation of normal movement sequences. We studied its role in coding initiation of a sequentially stereotyped but natural movement sequence by recording neuronal activity in SNpr during behavioural performance of 'syntactic grooming chains'. These are rule-governed sequences of up to 25 grooming movements emitted in four predictable (syntactic) phases, which occur spontaneously during grooming behaviour by rats and other rodents. Our results show that neuronal activation in central SNpr codes the onset of this entire rule-governed sequential pattern of grooming actions, not elemental grooming movements. We conclude that the context of sequential pattern may be more important than the elemental motor parameters in determining SNpr neuronal activation.
机译：运动序列在涉及基底神经节功能障碍的神经系统疾病（如帕金森氏病或图雷特氏综合症）中异常启动。黑质网纹（SNpr）是基底神经节的两个主要输出结构之一。但是，关于黑质如何介导正常运动序列的启动知之甚少。通过在“句法修饰链”的行为执行过程中记录SNpr中的神经元活动，我们研究了其在编码顺序定型但自然运动序列的启动中的作用。这些是规则控制的序列，在四个可预测的（句法）阶段中发出多达25个修饰运动，这些运动在大鼠和其他啮齿动物的修饰行为中自发地发生。我们的结果表明，中央SNpr中的神经元激活编码了整个规则控制的修饰动作而不是基本修饰动作的开始顺序。我们得出结论，在确定SNpr神经元激活时，顺序模式的上下文可能比基本运动参数更重要。

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