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首页> 外文期刊>The European Journal of Neuroscience >Reminder effects - reconsolidation or retrieval deficit? Pharmacological dissection with protein synthesis inhibitors following reminder for a passive-avoidance task in young chicks.
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Reminder effects - reconsolidation or retrieval deficit? Pharmacological dissection with protein synthesis inhibitors following reminder for a passive-avoidance task in young chicks.

机译：提醒作用-重新整合还是检索不足？在提醒雏鸡被动回避任务后，用蛋白质合成抑制剂进行药理学解剖。

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It is generally accepted that memory formation involves an irreversible passage via labile phases to the stable form of 'long-term memory' impervious to amnestic agents such as protein synthesis inhibitors. However, recent experiments demonstrate that reactivation of memory by way of a reminder renders it labile to such inhibitors, suggesting that such retrieval is followed by a so-called reconsolidation process similar or identical in its cellular and molecular correlates to that occurring during the initial consolidation. We compared the effects of the protein synthesis inhibitor anisomycin and the glycoprotein synthesis inhibitor 2-deoxygalactose on the temporal dynamics and pharmacological sensitivity of initial consolidation and memory expression following a reminder in a one-trial passive-avoidance task in day-old chicks. This comparison revealed three differences between the action of the inhibitors on newly formed compared with reactivated memory. First, the recall deficit after the reminder was temporary, whilst the amnesia following inhibitor treatment during training was stable. Second, the sensitive period for the effect of anisomycin was shorter in the reminder than in the training situation. Third, the effective dose for either inhibitor for reminder-associated amnesia was several times lower than for amnesia developing after training. Thus though like initial consolidation, memory expression at delayed periods following reminder depends on protein and glycoprotein synthesis, the differences between the temporal and pharmacological dynamics in the two situations point to the distinct character of the molecular processes involved in postreminder effects.
机译：通常公认的是，记忆形成涉及通过不稳定相不可逆转的通路，直至记忆消除剂如蛋白质合成抑制剂无法渗透的稳定形式的“长期记忆”。然而，最近的实验表明，通过提醒使记忆重新激活使其对此类抑制剂不稳定，这表明在这种恢复之后是所谓的重新整合过程，其细胞和分子相关性与初始整合过程相似或相同。 。我们比较了蛋白质合成抑制剂茴香霉素和糖蛋白合成抑制剂2-脱氧半乳糖对日间雏鸡一次试验的被动回避任务的提示后初始巩固和记忆表达的时间动态和药理敏感性的影响。该比较揭示了与重新激活的记忆相比，抑制剂对新形成的作用之间的三个差异。首先，提醒后的召回缺陷是暂时的，而训练期间抑制剂治疗后的健忘症是稳定的。第二，在提醒中对茴香霉素作用的敏感期短于在训练情况下。第三，与催眠相关的健忘症的任何一种抑制剂的有效剂量比训练后发展的健忘症的有效剂量低几倍。因此，尽管像最初的巩固一样，催眠后延迟期的记忆表达取决于蛋白质和糖蛋白的合成，但在两种情况下，时间和药理动力学之间的差异表明了与提醒后效应有关的分子过程的独特特征。

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