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首页> 外文期刊>The European Journal of Neuroscience >Intrinsic GABA neurons inhibit proenkephalin gene expression in slice cultures of rat neostriatum.
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Intrinsic GABA neurons inhibit proenkephalin gene expression in slice cultures of rat neostriatum.

机译：内在GABA神经元抑制大鼠新纹状体切片培养物中的前脑啡肽基因表达。

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In the neostriatum, the proenkephalin gene is expressed in medium spiny GABA neurons, which project to the globus pallidus. The expression is activated by glutamatergic projections from the neocortex via NMDA receptors. In these experiments we have used slice cultures of rat neostriatum to study the role of GABA in proenkephalin gene expression. Our results show that GABA is released from neostriatal neurons and negatively regulates the proenkephalin gene expression induced by NMDA receptor stimulation. The GABAA receptors involved seem to be colocalized with NMDA receptors on the projection neurons, which express the proenkephalin gene. In further experiments, we have found that the proenkephalin gene expression is not only activated by neocortical projection neurons but also by intrinsic striatal neurons as well as by projections from the thalamus. All these glutamatergic afferents enhance the proenkephalin gene expression via NMDA receptors. Their efficacy is regulated by endogenous GABA.
机译：在新纹状体中，前脑啡肽基因在中等棘状的GABA神经元中表达，该神经元投射到苍白球。该表达被来自新皮层的谷氨酸能投射经由NMDA受体激活。在这些实验中，我们使用大鼠新纹状体的切片培养物研究了GABA在脑啡肽原基因表达中的作用。我们的结果表明，GABA从新纹状体神经元释放，并负调控由NMDA受体刺激引起的前脑啡肽基因表达。参与的GABA A受体似乎与表达前脑啡肽基因的投射神经元上的NMDA受体共定位。在进一步的实验中，我们发现前脑啡肽基因的表达不仅被新皮层投射神经元激活，还被固有纹状体神经元以及丘脑的投射激活。所有这些谷氨酸能传入都通过NMDA受体增强前脑啡肽基因的表达。它们的功效由内源性GABA调节。

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