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首页> 外文期刊>The European Journal of Neuroscience >Locus coeruleus activation modulates firing rate and temporal organization of odour-induced single-cell responses in rat piriform cortex.
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Locus coeruleus activation modulates firing rate and temporal organization of odour-induced single-cell responses in rat piriform cortex.

机译：蓝斑蓝斑的活化调节大鼠梨状皮层中气味诱导的单细胞应答的放电速率和时间组织。

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摘要

Piriform cortex (PCx) is the primary cortical projection region for olfactory information and has bidirectional monosynaptic connections with olfactory bulb and association cortices. PCx neurons display a complex receptive field, responding to odours rather than their molecular components, suggesting that these neurons are involved in higher order olfactory processing. Neuromodulators, especially noradrenaline (NA), have important influences on sensory processing in other cortical regions and might be responsible for the plasticity observed in PCx during learning. The present study is the first attempt to examine in vivo the actions of NA on sensory responses in the PCx. Stimulation of the noradrenergic nucleus locus coeruleus (LC) was used to induce release of NA in the forebrain in urethane-anaesthetized rats. Extracellular recording of single units was made simultaneously in anterior and posterior PCx. The responses to an odour stimulus were measured over 25 trials. Twenty-five subsequent odour presentations were preceded by stimulation of the ipsilateral LC through a bipolar electrode, previously placed in the LC under electrophysiological control. This priming stimulation modified the activity of 77 of the 135 recorded neurons. For most cells, LC stimulation enhanced cortical responses to odour in terms of both spike count and temporal organization, with some differential effects in anterior and posterior regions. These results are the first to show enhancement of sensory responses in the olfactory cortex by LC activation. Spontaneous activation of LC neurons such as occurs during learning could serve to enhance olfactory perception and promote learning.
机译：梨状皮层（PCx）是嗅觉信息的主要皮质投影区域，与嗅球和缔合皮质具有双向单突触连接。 PCx神经元显示一个复杂的感受野，对气味而不是其分子成分做出反应，表明这些神经元参与了更高级别的嗅觉处理。神经调节剂，特别是去甲肾上腺素（NA），对其他皮质区域的感觉处理有重要影响，并且可能与学习过程中PCx的可塑性有关。本研究是体内检查NA对PCx感觉反应的作用的首次尝试。刺激去甲肾上腺素能核蓝斑（LC）以诱导尿烷麻醉大鼠前脑中NA的释放。在前后PCx中同时进行单个单元的细胞外记录。在25个试验中测量了对气味刺激的反应。在随后的25种气味呈现之前，先通过双极性电极刺激同侧LC，该双极性电极事先置于电生理控制下的LC中。这种启动刺激改变了135个记录的神经元中77个的活性。对于大多数细胞，LC刺激在峰值计数和时间组织方面都增强了皮质对气味的反应，在前部和后部区域产生了一些不同的影响。这些结果是第一个显示通过LC激活增强嗅觉皮层感觉反应的结果。 LC神经元的自发激活（例如在学习过程中发生）可能有助于增强嗅觉并促进学习。

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