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首页> 外文期刊>The European Journal of Neuroscience >Cholinergic responses in gabaergic and non-gabaergic neurons in the intermediate gray layer of mouse superior colliculus
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Cholinergic responses in gabaergic and non-gabaergic neurons in the intermediate gray layer of mouse superior colliculus

机译：小鼠上丘中间灰层的胆管能和非胆管能神经元的胆碱能反应

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Neurons in the intermediate gray layer (SGI) of the mammalian superior colliculus (SC) receive dense cholinergic innervations from the brainstem parabrachial region. Such cholinergic inputs may influence execution of orienting behaviors. To obtain deeper insights into how the cholinergic inputs modulate the SC local circuits, we analysed the cholinergic responses in identified γ-aminobutyric acid (GABA)ergic and non-GABAergic neurons using SC slices obtained from GAD67-GFP knock-in mice. The responses of SGI neurons to cholinergic agonists were various combinations of fast inward currents mediated mainly via α4β2 and partly by α7 nicotinic receptors (nIN), slow inward currents caused by activation of M1 plus M3 muscarinic receptors (mIN), and slow outward currents caused by activation of M2 muscarinic receptors (mOUT). The most common cholinergic responses in non-GABAergic neurons was nIN+mIN+mOUT (38/68), followed by nIN+mIN (16/68), nIN+mOUT (11/68), nIN only (2/68), and no response (1/68). On the other hand, the major response pattern in GABAergic neurons was either nIN only (26/54) or nIN+mIN (21/54), followed by nIN+mOUT (4/54), mOUT only (2/54), and no response (1/54). Thus, major effects of cholinergic inputs to both SGI GABAergic and non-GABAergic neurons are excitatory, but the response patterns in these two types of SGI neurons are different. Thus, actions of the cholinergic inputs to non-GABAergic and GABAergic SGI neurons are not simple push-pull mechanisms, like excitation vs inhibition, but might cooperate to balance the level of excitation and inhibition for setting the state of the response property of the local circuit.
机译：哺乳动物上丘（SC）的中间灰色层（SGI）中的神经元从臂干旁臂区接受密集的胆碱能神经支配。这样的胆碱能输入可能影响定向行为的执行。为了更深入地了解胆碱能输入如何调节SC局部回路，我们使用从GAD67-GFP敲入小鼠中获得的SC切片分析了已鉴定的γ-氨基丁酸（GABA）能和非GABA能神经元的胆碱能反应。 SGI神经元对胆碱能激动剂的反应是主要通过α4β2介导的快速内向电流（部分由α7烟碱受体（nIN）介导），由M1和M3毒蕈碱受体（mIN）激活引起的缓慢内向电流以及引起的缓慢外向电流的各种组合通过激活M2毒蕈碱受体（mOUT）。在非GABA能神经元中最常见的胆碱能反应是nIN + mIN + mOUT（38/68），其次是nIN + mIN（16/68），nIN + mOUT（11/68），仅nIN（2/68），而且没有回应（1/68）。另一方面，GABA能神经元的主要反应模式是仅nIN（26/54）或nIN + mIN（21/54），然后是nIN + mOUT（4/54），仅mOUT（2/54），而且没有回应（1/54）。因此，胆碱能输入对SGI GABA能神经元和非GABA能神经元的主要作用是兴奋性的，但在这两种SGI神经元中的反应方式是不同的。因此，胆碱能输入对非GABA能和GABA能SGI神经元的作用不是简单的推挽机制，如激发与抑制，但可以协同作用以平衡激发和抑制的水平，从而设定局部反应特性的状态。电路。

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