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首页> 外文期刊>The European Journal of Neuroscience >Subtype-dependent postnatal development of taste receptor cells in mouse fungiform taste buds
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Subtype-dependent postnatal development of taste receptor cells in mouse fungiform taste buds

机译：小鼠真菌形味蕾中味觉受体细胞的亚型依赖性产后发育

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摘要

Taste buds contain two types of taste receptor cells, inositol 1,4,5-triphosphate receptor type 3-immunoreactive cells (type II cells) and synaptosomal-associating protein-25-immunoreactive cells (type III cells). We investigated their postnatal development in mouse fungiform taste buds immunohistochemically and electrophysiologically. The cell density, i.e. the number of cells per taste bud divided by the maximal area of the horizontal cross-section of the taste bud, of type II cells increased by postnatal day (PD)49, where as that of type III cells was unchanged throughout the postnatal observation period and was equal to that of the adult cells at PD1. The immunoreactivity of taste bud cell subtypes was the same as that of their respective subtypes in adult mice throughout the postnatal observation period. Almost all type II cells were immunoreactive to gustducin at PD1, and then the ratio of gustducin-immunoreactive type II cells to all type II cells decreased to a saturation level, ~60% of all type II cells, by PD15. Type II and III cells generated voltage-gated currents similar to their respective adult cells even at PD3. These results show that infant taste receptor cells are as excitable as those of adults and propagate in a subtype-dependent manner. The relationship between the ratio of each taste receptor cell subtype to all cells and taste nerve responses are discussed.
机译：味蕾包含两种类型的味觉感受器细胞，肌醇1,4,5-三磷酸受体3型免疫反应性细胞（II型细胞）和与突触相关的蛋白25免疫反应性细胞（III型细胞）。我们通过免疫组织化学和电生理学研究了它们在小鼠真菌形味蕾中的产后发育。 II型细胞的细胞密度（即每个味蕾的细胞数除以味蕾水平横截面的最大面积）在出生后一天（PD）49之前增加，而III型细胞则保持不变在整个产后观察期中，与PD1的成年细胞相同。在整个产后观察期内，味蕾细胞亚型的免疫反应性与其成年小鼠的亚型的免疫反应性相同。几乎所有II型细胞在PD1时对gustducin都具有免疫反应性，然后通过PD15，gustducin免疫反应性II型细胞与所有II型细胞的比率降低至饱和水平，约占所有II型细胞的60％。 II型和III型细胞即使在PD3时也产生类似于其各自成年细胞的电压门控电流。这些结果表明，婴儿味觉受体细胞与成年人的一样兴奋，并以亚型依赖的方式繁殖。讨论了每种味觉受体细胞亚型与所有细胞的比例与味觉神经反应之间的关系。

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