• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Diversity of thalamic progenitor cells and postmitotic neurons
【24h】

Diversity of thalamic progenitor cells and postmitotic neurons

机译：丘脑祖细胞和有丝分裂后神经元的多样性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The vertebrate thalamus contains multiple sensory nuclei, and relays sensory information to corresponding cortical areas. Moreover, the thalamus actively regulates information transmission to the cortex by modulating the response magnitude, firing mode and synchrony of neurons according to behavioral demands. The thalamus serves many other functions including motor control, learning and memory, and emotion. Such functional importance of the thalamus necessitates a better understanding of its developmental mechanisms. In this review, we will first describe the morphological organization of the developing thalamus. We will then discuss how neuronal diversity is generated and nuclei are formed during thalamic development. The first step in generating neuronal diversity is the formation of spatial diversity of thalamic progenitor cells, which is controlled by locally-expressed signaling molecules such as Sonic hedgehog (Shh), Wnt proteins and Fgf8. Lastly we will describe the roles of several transcription factors in specification of neuronal identity and nuclei formation in the thalamus. Our review will provide a molecular perspective for the organization of the thalamus prior to thalamus-cortex circuit formation.
机译：脊椎动物丘脑包含多个感觉核，并将感觉信息传递到相应的皮质区域。此外，丘脑根据行为需求通过调节神经元的反应幅度，发射方式和同步性来主动调节信息传递至皮层。丘脑还具有许多其他功能，包括运动控制，学习和记忆以及情感。丘脑的这种功能重要性需要更好地了解其发育机制。在这篇综述中，我们将首先描述发育中的丘脑的形态组织。然后，我们将讨论丘脑发育过程中如何产生神经元多样性和形成核。产生神经元多样性的第一步是丘脑祖细胞的空间多样性的形成，这是由局部表达的信号分子（如声波刺猬（Shh），Wnt蛋白和Fgf8）控制的。最后，我们将描述一些转录因子在丘脑神经元身份和细胞核形成的规范中的作用。我们的综述将为丘脑-皮层回路形成之前丘脑的组织提供分子视角。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号