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首页> 外文期刊>The European Journal of Neuroscience >Variability in step training enhances locomotor recovery after a spinal cord injury
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Variability in step training enhances locomotor recovery after a spinal cord injury

机译：步进训练的可变性可增强脊髓损伤后的运动能力恢复

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摘要

Performance of a motor task is improved by practicing a specific task with added 'challenges' to a training regimen. We tested the hypothesis that, in the absence of brain control, the performance of a motor task is enhanced by training using specific variations of that task. We utilized modifications of step performance training to improve the ability of spinal rats to forward step. After a complete thoracic spinal cord transection, 20 adult rats were divided randomly to bipedally step on a treadmill in the forward, sideward, or backward direction for 28 sessions (20min, 5days/week) and subsequently tested for their ability to step in the forward direction. Although the animals from all trained groups showed improvement, the rats in the sideward-trained and backward-trained groups had greater step consistency and coordination along with higher peak amplitudes and total integrated activity of the rectified electromyographic signals from selected hindlimb muscles per step during forward stepping than the rats in the forward-trained group. Our results demonstrate that, by retaining the fundamental features of a motor task (bipedal stepping), the ability to perform that motor task can be enhanced by the addition of specific contextual variations to the task (direction of stepping). Our data suggest that the forward stepping neuronal locomotor networks are partially complemented by synchronous activation of interneuronal/motoneuronal populations that are also a part of the sideward or backward stepping locomotor networks. Accordingly, the overlap and interaction of neuronal elements may play a critical role in positive task transference.
机译：通过执行特定任务并增加训练方案的“挑战性”，可以提高运动任务的性能。我们测试了以下假设：在没有大脑控制的情况下，通过使用该任务的特定变体进行训练可以增强运动任务的性能。我们利用对步态性能训练的改进来提高脊柱大鼠前进步的能力。完全切除胸椎脊髓后，将20只成年大鼠随机分为两部分，分别在跑步机上向前，侧向或向后踩踏28次（20分钟，5天/周），然后测试其向前踩踏的能力方向。尽管所有训练组的动物均表现出改善，但侧向训练和向后训练组中的大鼠在前进过程中具有更高的步长一致性和协调性，并具有更高的峰值幅度和每步选定后肢肌肉的整流肌电图信号的总整合活性在向前训练组中要比在大鼠中踩踏。我们的结果表明，通过保留运动任务（双足踏步）的基本特征，可以通过向任务（步移方向）添加特定的上下文变化来增强执行该运动任务的能力。我们的数据表明，向前步进的神经元运动网络被同步激活的神经元间/运动神经元群体部分补充，这也是侧向或向后步进运动网络的一部分。因此，神经元元件的重叠和相互作用可能在积极的任务转移中起关键作用。

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