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首页> 外文期刊>The European Journal of Neuroscience >Changes in nucleus accumbens and neostriatal c-Fos and DARPP-32 immunoreactivity during different stages of food-reinforced instrumental training
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Changes in nucleus accumbens and neostriatal c-Fos and DARPP-32 immunoreactivity during different stages of food-reinforced instrumental training

机译：食物强化器械训练不同阶段伏伏核和新纹状体c-Fos和DARPP-32免疫反应性的变化

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摘要

Nucleus accumbens is involved in several aspects of instrumental behavior, motivation and learning. Recent studies showed that dopamine (DA) release in the accumbens shell was significantly increased on the first day of training on a fixed ratio (FR) 5 schedule (i.e. the transition from FR1 to FR5) compared with those rats that continued FR1 training, even though the rats on their first day of FR5 training received less food reinforcement than rats continuing on the FR1 schedule. Additionally, the second day of FR5 responding was marked by a significant increase in DA release in accumbens core. The present studies employed immunohistochemical methods to characterize the changes in cellular markers of accumbens and neostriatal neural activity that occur during various stages of food-reinforced FR5 training. c-Fos and DARPP-32 immunoreactivity in accumbens shell was significantly increased on the first day of FR5 training, while core c-Fos and DARPP-32 expression showed large increases on the second day of FR5 training. Additional studies showed that c-Fos and DARPP-32 expression in neostriatum increased after more extensive training. Double-labeling studies with immunofluorescence methods indicated that increases in accumbens c-Fos and DARPP-32 expression were primarily seen in substance-P-positive neurons. These increases in accumbens c-Fos and DARPP-32 immunoreactivity seen during the initial phases of FR training may reflect several factors, including novelty, learning, stress or the presentation of a work-related challenge to the organism. Moreover, it appears that the separate subregions of the striatal complex are differentially activated at distinct phases of instrumental training.
机译：伏伏核涉及工具行为，动机和学习的多个方面。最近的研究表明，在训练的第一天，按照固定比例（FR）5的时间表（即从FR1过渡到FR5），多巴胺（DA）的释放显着增加，甚至比那些继续进行FR1训练的大鼠（甚至尽管在进行FR5训练的第一天，老鼠的食物强化作用少于继续按照FR1计划的老鼠。此外，FR5反应的第二天，伏安核心的DA释放显着增加。本研究采用免疫组织化学方法来表征在食物强化的FR5训练的各个阶段发生的伏隔细胞标志物和新纹状体神经活动的变化。在FR5训练的第一天，伏打蛋壳中的c-Fos和DARPP-32免疫反应性显着增加，而在FR5训练的第二天，核心c-Fos和DARPP-32的表达则显着增加。其他研究表明，经过更广泛的训练后，新纹状体中的c-Fos和DARPP-32表达增加。用免疫荧光方法进行的双标记研究表明，伏隔蛋白c-Fos和DARPP-32表达的增加主要见于P物质阳性的神经元。在FR训练的初始阶段，这些患者的c-Fos和DARPP-32免疫反应性增加，可能反映了多种因素，包括新颖性，学习性，压力或对生物体提出与工作有关的挑战。而且，似乎在仪器训练的不同阶段，纹状体复合体的各个子区域被不同地激活。

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