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Cellular and molecular mechanisms controlling the migration of neocortical interneurons

机译:控制新皮层神经元迁移的细胞和分子机制

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摘要

The discovery, approximately 15 years ago, that cortical GABAergic interneurons originate outside the pallium has revolutionized our understanding of the development of the cerebral cortex. It is now clear that glutamatergic pyramidal cells and GABAergic interneurons follow largely distinct development programs, a notion that has challenged our views on how these neurons assemble to form precise neural circuits. In this review, I summarize our current knowledge of the mechanisms that control the migration of neocortical interneurons, a process that can be subdivided into three consecutive phases: migration to the cortex, intracortical dispersion, and layering.
机译:大约15年前的发现,皮质GABA能神经元起源于大脑皮层之外,这彻底改变了我们对大脑皮质发育的理解。现在很明显,谷氨酸能锥体细胞和GABA能神经元遵循不同的发育程序,这一观念已经挑战了我们关于这些神经元如何组装形成精确的神经回路的观点。在这篇综述中,我总结了我们目前对控制新皮层神经元迁移的机制的知识,该过程可以细分为三个连续的阶段:向皮层迁移,皮层内弥散和分层。

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