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首页> 外文期刊>The European Journal of Neuroscience >Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain
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Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain

机译：热量限制可缓解与衰老有关的大脑中神经祖细胞分裂的年龄相关性下降

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Production of new neurons from stem cells is important for cognitive function, and the reduction of neurogenesis in the aging brain may contribute to the accumulation of age-related cognitive deficits. Restriction of calorie intake and prolonged treatment with rapamycin have been shown to extend the lifespan of animals and delay the onset of the age-related decline in tissue and organ function. Using a reporter line in which neural stem and progenitor cells are marked by the expression of green fluorescent protein (GFP), we examined the effect of prolonged exposure to calorie restriction (CR) or rapamycin on hippocampal neural stem and progenitor cell proliferation in aging mice. We showed that CR increased the number of dividing cells in the dentate gyrus of female mice. The majority of these cells corresponded to nestin-GFP-expressing neural stem or progenitor cells; however, this increased proliferative activity of stem and progenitor cells did not result in a significant increase in the number of doublecortin-positive newborn neurons. Our results suggest that restricted calorie intake may increase the number of divisions that neural stem and progenitor cells undergo in the aging brain of females. We examined the response of adult stem and progenitor cells in the hippocampus to an extended period of calorie restriction and rapamycin supplementation by using a reporter mouse line in which expression of GFP marks adult stem and progenitor cells. Upper left image shows the hippocampus of a young (3 weeks) animal for comparison. We found that calorie restriction increases proliferation of neural stem and progenitor cells in aging females.
机译：干细胞产生新的神经元对于认知功能很重要，而衰老大脑中神经发生的减少可能有助于与年龄有关的认知缺陷的积累。限制卡路里摄入和雷帕霉素长期治疗可延长动物的寿命，并延缓与年龄有关的组织和器官功能下降的发作。使用绿色荧光蛋白（GFP）表达标记神经干细胞和祖细胞的报告基因，我们研究了长时间暴露于卡路里限制（CR）或雷帕霉素对衰老小鼠海马神经干细胞和祖细胞增殖的影响。我们表明，CR增加了雌性小鼠齿状回中分裂细胞的数量。这些细胞中的大多数对应于表达巢蛋白-GFP的神经干细胞或祖细胞。然而，这种干细胞和祖细胞增殖活性的提高并未导致双皮质素阳性新生神经元数量的显着增加。我们的结果表明，卡路里摄入受限可能会增加女性衰老的大脑中神经干细胞和祖细胞的分裂数量。我们通过使用其中GFP的表达标记成年干细胞和祖细胞的报告基因小鼠系检查了海马中成年干细胞和祖细胞对延长的卡路里限制和雷帕霉素补充的反应。左上方的图像显示了一只幼小（3周）动物的海马，以进行比较。我们发现卡路里限制会增加衰老女性中神经干细胞和祖细胞的增殖。

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