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首页> 外文期刊>The European Journal of Neuroscience >Brain-derived neurotrophic factor interacts with astrocytes and neurons to control respiration
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Brain-derived neurotrophic factor interacts with astrocytes and neurons to control respiration

机译：脑源性神经营养因子与星形胶质细胞和神经元相互作用以控制呼吸

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摘要

Respiratory rhythm is generated and modulated in the brainstem. Neuronal involvement in respiratory control and rhythmogenesis is now clearly established. However, glial cells have also been shown to modulate the activity of brainstem respiratory groups. Although the potential involvement of other glial cell type(s) cannot be excluded, astrocytes are clearly involved in this modulation. In parallel, brain-derived neurotrophic factor (BDNF) also modulates respiratory rhythm. The currently available data on the respective roles of astrocytes and BDNF in respiratory control and rhythmogenesis lead us to hypothesize that there is BDNF-mediated control of the communication between neurons and astrocytes in the maintenance of a proper neuronal network capable of generating a stable respiratory rhythm. According to this hypothesis, progression of Rett syndrome, an autism spectrum disease with disordered breathing, can be stabilized in mouse models by re-expressing the normal gene pattern in astrocytes or microglia, as well as by stimulating the BDNF signaling pathway. These results illustrate how the signaling mechanisms by which glia exerts its effects in brainstem respiratory groups is of great interest for pathologies associated with neurological respiratory disorders.
机译：呼吸节律在脑干中产生并调节。现已明确确定神经元参与呼吸控制和节律。然而，神经胶质细胞也已被证明可调节脑干呼吸群的活动。尽管不能排除其他神经胶质细胞类型的潜在参与，但星形胶质细胞显然参与了这种调节。同时，脑源性神经营养因子（BDNF）也可调节呼吸节律。目前有关星形胶质细胞和BDNF在呼吸控制和节律发生中的各自作用的现有数据使我们假设，在维持能够产生稳定呼吸节奏的适当神经元网络的维持过程中，存在BDNF介导的神经元和星形胶质细胞之间的通信控制。 。根据该假设，可以通过在星形胶质细胞或小胶质细胞中重新表达正常基因模式以及刺激BDNF信号传导途径，在小鼠模型中稳定Rett综合征（一种呼吸紊乱的自闭症谱系疾病）的进展。这些结果说明了神经胶质在脑干呼吸群中发挥作用的信号传导机制如何引起与神经性呼吸系统疾病相关的病理学的极大兴趣。

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