The neurobiology of aging and Alzheimer's disease: Walking down the same road?

JannicB.; KarlF.; NicoleL.; RichardR.

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The neurobiology of aging and Alzheimer's disease: Walking down the same road?

机译：衰老和阿尔茨海默氏病的神经生物学：走同一条路？

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The cognitive impairments associated with aging and age-related diseases are a major socio-economic concern for the world's rapidly growing older population. As we get older, subtle changes in nervous system biology manifest as altered sleeping patterns, impaired sensory-motor coordination, mood changes, and impairments in learning and memory. Although, in most people, these deteriorations do not reach the level of incapacitating impairments, they impact the life of a large proportion of aging people. Aging-related changes in neural function can occur at dramatically different rates across individuals and populations, and there is evidence for the involvement of both genetic and environmental risk factors. However, the neurobiological mechanisms affected at the network, cellular and molecular levels are only slowly becoming clearer.

机译：与衰老和与年龄有关的疾病相关的认知障碍是世界上快速增长的老年人口的主要社会经济问题。随着年龄的增长，神经系统生物学的细微变化表现为睡眠方式改变，感觉运动协调受损，情绪变化以及学习和记忆障碍。尽管在大多数人中，这些恶化并没有达到丧失能力的程度，但它们却影响了大部分老年人的生活。与衰老相关的神经功能变化在个体和人群中的发生率可能有显着差异，并且有证据表明遗传和环境风险因素均参与其中。但是，在网络，细胞和分子水平受到影响的神经生物学机制只是逐渐变得更加清晰。

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《The European Journal of Neuroscience》 |2013年第12期|共2页
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JannicB.; KarlF.; NicoleL.; RichardR.;
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中图分类神经病学与精神病学;
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1. The neurobiology of aging and Alzheimer's disease: Walking down the same road? [J] . JannicB., KarlF., NicoleL., The European Journal of Neuroscience . 2013,第11a12期

机译：衰老和阿尔茨海默氏病的神经生物学：走同一条路？
2. Corrigendum to “Deficits in synaptic function occur at medial perforant path-dentate granule cell synapses prior to Schaffer collateral-CA1 pyramidal cell synapses in the novel TgF344-Alzheimer's Disease Rat Model” [Neurobiology of Disease Volume 110, February 2018, Pages 166–179] [J] . Lindsey A. Smith, Lori L. McMahon Neurobiology of disease . 2018,第期

机译：在新型TGF344-Alzheimer疾病大鼠模型中Schaffer壳体-CA1金字塔模型之前，“突触函数缺陷发生的突触函数缺陷发生的静脉曲张术”[2018年2月的疾病1月110日，第166-179页 ]
3. Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants older than 60 years with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study (vol 391, pg 339, 2017) [J] . Sinharay R., Gong J., Barratt B., The Lancet . 2018,第10118期

机译：与慢性肺或心脏病和年龄匹配的健康对照组（患者）的参与者的无交通区域相比，呼吸和心血管反应走在交通污染的道路上，与慢性肺或心脏病和健康的健康对照组：随机交叉研究（Vol 391，PG 339,2017）
4. A Study of the Indoor Walking Navigation System for Patients with Early-stage Alzheimer's Disease [C] . Yung-Ching Liu, Yang-Kun Ou, Sung-Nung Lin, International Conference on Computer, Networks and Communication Engineering . 2013

机译：早期阿尔茨海默病患者室内行走导航系统研究
5. The neurobiology of apolipoprotein E: Protein interactions in Alzheimer's disease. [D] . Petit-Turcotte, Caroline. 2004

机译：载脂蛋白E的神经生物学：阿尔茨海默氏病中的蛋白质相互作用。
6. Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised crossover study [O] . Rudy Sinharay, Jicheng Gong, Benjamin Barratt, -1

机译：在60岁及以上患有慢性肺病或心脏病并与年龄相匹配的健康对照的参与者中与在无交通区行走相比在有交通污染的道路上行走时呼吸和心血管反应：一项随机交叉研究
7. Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls:A randomised, crossover study [O] . Sinharay Rudy, Gong Jicheng, Barratt Benjamin, 2017

机译：在60岁及以上患有慢性肺病或心脏病并与年龄相匹配的健康对照的参与者中，与在无交通区行走相比，在有交通污染的道路上行走时的呼吸和心血管反应：一项随机交叉研究
8. Il Contributo delle Unita di Valutazione Alzheimer (UVA) Nell'Assistenza dei Pazienti con Demenza. 2nd Congress held in Istituto Superiore di Sanita Roma, on 25 Settembre 2008. Riassunti (The Impact of Alzheimer Disease Unites in the management of Patient [R] . Ruggerli, P., Vanacore, N. 2008

机译：Il Contributo delle Unita di Valutazione alzheimer（UVa）Nell'assistenza dei pazienti con Demenza。第二届大会于2008年5月25日在Istituto superiore di sanita Roma举行.Riassunti（阿尔茨海默病联盟对患者管理的影响）

The neurobiology of aging and Alzheimer's disease: Walking down the same road?

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