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首页> 外文期刊>The European Journal of Neuroscience >Beta2 oscillations (23-30 Hz) in the mouse hippocampus during novel object recognition
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Beta2 oscillations (23-30 Hz) in the mouse hippocampus during novel object recognition

机译：新型对象识别过程中小鼠海马体中的Beta2振荡（23-30 Hz）

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The oscillatory activity of hippocampal neuronal networks is believed to play a role in memory acquisition and consolidation. Particular focus has been given to characterising theta (4-12Hz), gamma (40-100Hz) and ripple (150-250Hz) oscillations. Beyond these well-described network states, few studies have investigated hippocampal beta2 (23-30Hz) activity in vivo and its link to behaviour. A previous sudy showed that the exploration of novel environments may lead to the appearance of beta2 oscillations in the mouse hippocampus. In the present study we characterised hippocampal beta2 oscillations in mice during an object recognition task. We found prominent bursts of beta2 oscillations in the beginning of novel exploration sessions (four new objects), which could be readily observed by spectral analysis and visual inspection of local field potentials. Beta2 modulated hippocampal but not neocortical neurons and its power decreased along the session. We also found increased beta2 power in the beginning of a second exploration session performed 24h later in a slightly modified environment (two new, two familiar objects), but to a lesser extent than in the first session. However, the increase in beta2 power in the second exploration session became similar to the first session when we pharmacologically impaired object recognition in a new set of experiments performed 1week later. Our results suggest that hippocampal beta2 activity is associated with a dynamic network state tuned for novelty detection and which may allow new learning to occur.
机译：据信海马神经元网络的振荡活动在记忆获得和巩固中起作用。特别关注的是表征θ（4-12Hz），γ（40-100Hz）和纹波（150-250Hz）振荡。除了这些良好描述的网络状态外，很少有研究调查体内海马β2（23-30Hz）活性及其与行为的联系。先前的研究表明，探索新环境可能导致小鼠海马体中出现beta2振荡。在本研究中，我们在对象识别任务过程中表征了小鼠海马β2振荡。我们在新颖的探索阶段（四个新物体）的开始阶段发现了明显的beta2振荡爆发，可以通过频谱分析和局部场电势的目测轻松观察到。 Beta2调节海马而不是新皮层神经元，并且其功率在整个过程中下降。我们还发现，在稍有修改的环境（两个新的，两个熟悉的物体）中进行的第二次探索会话开始后的24小时内，beta2的能力增加了，但程度却比第一次对话低。但是，当我们在1周后进行的一组新实验中，药理上损害了对象识别时，第二次探索阶段中beta2功能的增加变得与第一阶段相似。我们的结果表明，海马beta2活性与为检测新奇而调整的动态网络状态相关，这可能允许发生新的学习。

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