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首页> 外文期刊>The European Journal of Neuroscience >Differential role of N-methyl-D-aspartate receptor-mediated glutamate transmission in the nucleus accumbens shell and core in nicotine seeking in rats
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Differential role of N-methyl-D-aspartate receptor-mediated glutamate transmission in the nucleus accumbens shell and core in nicotine seeking in rats

机译：N-甲基-D-天冬氨酸受体介导的谷氨酸传递在大鼠尼古丁寻找中伏伏核壳和核中的不同作用

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Nicotine, a major psychoactive component of tobacco smoke, increases glutamate transmission in the nucleus accumbens (NAcc). However, the role of the N-methyl-D-aspartate (NMDA)-mediated glutamatergic neurotransmission in the NAcc shell and core subdivisions in nicotine-dependent behaviors has not been studied. The present study evaluated, in rats, the effects of bilateral administration of the competitive NMDA receptor antagonist LY235959 (0, 0.1, 1, and 10 ng/0.5 μL/side) into the NAcc shell or core on intravenous nicotine (fixed- and progressive-ratio schedules) and food (fixed-ratio schedule) self-administration, and cue-induced reinstatement of nicotine-seeking behavior. In addition, the effects of LY235959 injections in the NAcc shell were evaluated on nicotine-induced conditioned taste aversion, a procedure that assesses the aversive effects of nicotine. LY235959 injections into the NAcc shell significantly increased nicotine self-administration under both fixed- and progressive-ratio schedules, and decreased food self-administration, but had no effect on nicotine-induced conditioned taste aversion or cue-induced nicotine seeking. Furthermore, injections of LY235959 in the lateral septal nucleus, originally intended as an anatomical control site for the NAcc shell, increased nicotine self-administration and decreased food self-administration under the fixed-ratio schedule. In contrast, LY235959 injections into the NAcc core increased the cue-induced reinstatement of nicotine seeking and decreased food self-administration, but had no effect on nicotine self-administration. The present data suggest that NMDA receptor-mediated glutamatergic neurotransmission in the NAcc shell and core differentially regulates food- and nicotine-maintained responding. Importantly, the data suggest an inhibitory role for NMDA-mediated glutamatergic neurotransmission in the NAcc shell and core in nicotine self-administration and the cue-induced reinstatement of nicotine seeking, respectively.
机译：尼古丁是烟草烟雾中的主要精神活性成分，可增加伏隔核（NAcc）中的谷氨酸传递。然而，尚未研究N-甲基-D-天冬氨酸（NMDA）介导的谷氨酸能神经传递在尼古丁依赖性行为中NAcc壳和核心细分中的作用。本研究在大鼠中评估了将竞争性NMDA受体拮抗剂LY235959（0、0.1、1和10 ng / 0.5μL/侧）双向施用到NAcc壳或核中对静脉内尼古丁（固定和进行性）的影响-比例计划）和食物（固定比例计划）自我管理，以及提示诱导的尼古丁寻找行为的恢复。另外，在尼古丁诱导的条件性味觉厌恶上评估了LY235959注射在NAcc壳中的作用，该过程评估了尼古丁的厌恶作用。 LY235959注射到NAcc壳中可以在固定比例和渐进比例下显着增加尼古丁的自我管理，并减少食品的自我管理，但对尼古丁引起的条件性口味厌恶或提示诱导的尼古丁搜寻没有影响。此外，在固定间隔的时间表下，最初打算将NA235壳用作解剖控制部位的外侧中隔核注射LY235959，可以增加尼古丁的自我管理，并减少食品的自我管理。相反，向NAcc核心注射LY235959可以增加线索诱导的尼古丁寻找的恢复，并减少食品的自我管理，但对尼古丁的自我管理没有影响。目前的数据表明，NAcc壳和核中NMDA受体介导的谷氨酸能神经传递差异地调节食物和尼古丁维持的应答。重要的是，数据提示NMDA介导的谷氨酸能神经传递在尼古丁自我给药和提示诱导的尼古丁寻找恢复中分别在NAcc壳和核中具有抑制作用。

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