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首页> 外文期刊>The European Journal of Neuroscience >Inverted-U shaped effects of D1 dopamine receptor stimulation in the medial preoptic nucleus on sexually motivated song in male European starlings
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Inverted-U shaped effects of D1 dopamine receptor stimulation in the medial preoptic nucleus on sexually motivated song in male European starlings

机译：视前内侧核中D1多巴胺受体刺激的倒U型效应对欧洲八哥sexual性动机歌曲的影响

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Past studies in songbirds have highlighted a central role for the medial preoptic nucleus (mPOA) in context-appropriate vocal communication. During the breeding season, male songbirds sing primarily to attract females (sexually motivated song) and to repel competitors (agonistically motivated song). Past data have linked dopamine and D1 dopamine receptors in the mPOA to sexually motivated but not agonistically motivated song; however, direct effects of dopamine receptor manipulations in the mPOA on song have not been experimentally tested. Here, we tested the hypothesis that D1 receptor stimulation in the mPOA selectively influences sexually motivated male song, and the possibility that the effects of D1 receptor agonism differ at low and high doses. In a first study, breeding-condition male European starlings received infusions of saline or a single dose of the D1 receptor agonist SKF 38393 on separate test days into the mPOA or hypothalamic control areas. Stimulation of D1 receptors in the mPOA triggered sexually motivated but not agonistically motivated song. A second study showed inverted-U shaped dose-response effects of the agonist, such that low levels of sexually motivated song were observed at low and high levels of D1 receptor activation. A third study showed that the effects of the D1 receptor agonist were blocked by the D1 receptor antagonist SCH 23390. These findings suggest that an optimal level of D1 receptor stimulation in the mPOA is needed to facilitate sexually motivated vocal production. The results support a central, context-specific role for the mPOA in vocal communication, and more broadly demonstrate a complex, modulatory influence of D1 receptors in the mPOA on sexually motivated behavior.
机译：过去有关鸣禽的研究强调了视前内侧核（mPOA）在与情境相适应的语音交流中的核心作用。在繁殖季节，雄性鸣鸟唱歌主要是为了吸引雌性（有性动机的歌曲）并击退竞争对手（有刺激性的歌曲）。过去的数据已将mPOA中的多巴胺和D1多巴胺受体与性动机而非激动性歌曲联系在一起。但是，尚未通过实验测试mPOA中多巴胺受体操纵对歌曲的直接影响。在这里，我们测试了mPOA中D1受体刺激选择性影响性动机男性歌曲的假设，以及D1受体激动作用在低剂量和高剂量下均不同的可能性。在第一项研究中，有繁殖条件的欧洲八哥种在单独的测试日内接受了生理盐水或单剂量D1受体激动剂SKF 38393的输注，进入mPOA或下丘脑控制区域。 mPOA中D1受体的刺激触发了性动机但不是激动性的歌曲。第二项研究显示了激动剂的倒U型剂量反应效应，因此在低水平和高水平的D1受体激活下都观察到低水平的性动机歌曲。第三项研究表明，D1受体拮抗剂SCH 23390阻断了D1受体激动剂的作用。这些发现表明，在mPOA中需要最佳水平的D1受体刺激来促进性动机声的产生。这些结果支持了mPOA在语音交流中的中心，特定于上下文的作用，并且更广泛地证明了mPOA中D1受体对性动机行为的复杂调节作用。

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