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首页> 外文期刊>The European Journal of Neuroscience >The vomeronasal cortex - afferent and efferent projections of the posteromedial cortical nucleus of the amygdala in mice
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The vomeronasal cortex - afferent and efferent projections of the posteromedial cortical nucleus of the amygdala in mice

机译：犁鼻鼻皮质-小鼠杏仁核后内侧皮质核的传入和传出投影

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摘要

Most mammals possess a vomeronasal system that detects predominantly chemical signals of biological relevance. Vomeronasal information is relayed to the accessory olfactory bulb (AOB), whose unique cortical target is the posteromedial cortical nucleus of the amygdala. This cortical structure should therefore be considered the primary vomeronasal cortex. In the present work, we describe the afferent and efferent connections of the posteromedial cortical nucleus of the amygdala in female mice, using anterograde (biotinylated dextranamines) and retrograde (Fluorogold) tracers, and zinc selenite as a tracer specific for zinc-enriched (putative glutamatergic) projections. The results show that the posteromedial cortical nucleus of the amygdala is strongly interconnected not only with the rest of the vomeronasal system (AOB and its target structures in the amygdala), but also with the olfactory system (piriform cortex, olfactory-recipient nuclei of the amygdala and entorhinal cortex). Therefore, the posteromedial cortical nucleus of the amygdala probably integrates olfactory and vomeronasal information. In addition, the posteromedial cortical nucleus of the amygdala shows moderate interconnections with the associative (basomedial) amygdala and with the ventral hippocampus, which may be involved in emotional and spatial learning (respectively) induced by chemical signals. Finally, the posteromedial cortical nucleus of the amygdala gives rise to zinc-enriched projections to the ventrolateral septum and the ventromedial striatum (including the medial islands of Calleja). This pattern of intracortical connections (with the olfactory cortex and hippocampus, mainly) and cortico-striatal excitatory projections (with the olfactory tubercle and septum) is consistent with its proposed nature as the primary vomeronasal cortex.
机译：大多数哺乳动物都具有犁鼻系统，该系统主要检测具有生物学相关性的化学信号。 Vomeronasal信息被传递到副嗅球（AOB），其唯一的皮质靶标是杏仁核的后内侧皮质核。因此，该皮质结构应被视为主要的前鼻窦皮质。在当前的工作中，我们使用顺行（生物素化的葡聚糖胺）和逆行（Fluorogold）示踪剂，以及亚硒酸锌作为富锌的示踪剂，描述雌性小鼠杏仁核后内侧皮质核的传入和传出连接。谷氨酸能）预测。结果表明，杏仁核的后内侧皮质核不仅与其余的犁鼻系统（杏仁核中的AOB及其靶结构）紧密相连，而且与嗅觉系统（梨状皮层，嗅觉受体核）紧密相连。杏仁核和内嗅皮层）。因此，杏仁核的后内侧皮质核可能整合了嗅觉信息和犁鼻信息。此外，杏仁核的后内侧皮质核显示出与缔合（巴氏体）杏仁核和腹侧海马的适度互连，这可能分别涉及由化学信号诱导的情绪和空间学习。最后，杏仁核的后内侧皮层核使腹侧隔和腹侧纹状体（包括Calleja的内侧岛）产生富锌的突出物。皮质内连接（主要与嗅觉皮层和海马）和皮质-纹状体兴奋性投射（嗅觉结节和中隔）的这种模式与其拟议的作为原发性鼻窦皮质的性质相一致。

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