...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Rebound spiking properties of mouse medial entorhinal cortex neurons in vivo
【24h】

Rebound spiking properties of mouse medial entorhinal cortex neurons in vivo

机译：体内小鼠内侧内嗅皮层神经元的反弹尖峰特性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The medial entorhinal cortex is the gateway between the cortex and hippocampus, and plays a critical role in spatial coding as represented by grid cell activity. In the medial entorhinal cortex, inhibitory circuits are robust, and the presence of the h-current leads to rebound potentials and rebound spiking in in vitro experiments. It has been hypothesized that these properties, combined with network oscillations, may contribute to grid cell formation. To examine the properties of in vivo rebound spikes, we performed whole-cell patch-clamp recordings in medial entorhinal cortex neurons in anaesthetized mice. We injected hyperpolarizing inputs representing inhibitory synaptic inputs along with sinusoidal oscillations and found that hyperpolarizing inputs injected at specific phases of oscillation had a higher probability of inducing subsequent spikes at the peak of the oscillation in some neurons. This effect was prominent in the cells with large sag potential, which is a marker of the h-current. In addition, larger and longer hyperpolarizing current square-pulse stimulation resulted in a larger probability of eliciting rebound spikes, though we did not observe a relationship between the amplitude or duration of hyperpolarizing current pulse stimulation and the delay of rebound spikes. Overall these results suggest that rebound spikes are observed in vivo and may play a role in generating grid cell activity in medial entorhinal cortex neurons.
机译：内侧内嗅皮层是皮层和海马之间的门户，并在以网格细胞活动为代表的空间编码中起着至关重要的作用。在内侧内嗅皮层中，抑制回路很强，并且在体外实验中，h电流的存在会导致反弹电位和反弹尖峰。据推测，这些特性与网络振荡相结合，可能有助于网格单元的形成。为了检查体内反弹尖峰的特性，我们在麻醉小鼠的内侧内嗅皮层神经元中进行了全细胞膜片钳记录。我们注入了代表抑制性突触输入和正弦振荡的超极化输入，发现在特定振荡阶段注入的超极化输入在某些神经元的振荡峰值处具有较高的诱发随后尖峰的可能性。这种作用在具有高流挂电位的细胞中很明显，这是h-电流的标志。另外，虽然我们没有观察到超极化电流脉冲刺激的幅度或持续时间与反弹尖峰延迟之间的关系，但是更大和更长的超极化电流方脉冲刺激导致引起反弹尖峰的可能性更大。总的来说，这些结果表明，在体内观察到反弹峰值，并且可能在内侧内嗅皮层神经元中产生网格细胞活性中起作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号