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首页> 外文期刊>The European Journal of Neuroscience >Perirhinal cortex lesions impair tests of object recognition memory but spare novelty detection
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Perirhinal cortex lesions impair tests of object recognition memory but spare novelty detection

机译：周围神经皮层病变削弱了物体识别记忆的测试能力，但缺乏新颖性检测

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摘要

The present study examined why perirhinal cortex lesions in rats impair the spontaneous ability to select novel objects in preference to familiar objects, when both classes of object are presented simultaneously. The study began by repeating this standard finding, using a test of delayed object recognition memory. As expected, the perirhinal cortex lesions reduced the difference in exploration times for novel vs. familiar stimuli. In contrast, the same rats with perirhinal cortex lesions appeared to perform normally when the preferential exploration of novel vs. familiar objects was tested sequentially, i.e. when each trial consisted of only novel or only familiar objects. In addition, there was no indication that the perirhinal cortex lesions reduced total levels of object exploration for novel objects, as would be predicted if the lesions caused novel stimuli to appear familiar. Together, the results show that, in the absence of perirhinal cortex tissue, rats still receive signals of object novelty, although they may fail to link that information to the appropriate object. Consequently, these rats are impaired in discriminating the source of object novelty signals, leading to deficits on simultaneous choice tests of recognition.
机译：本研究探讨了当两种对象同时出现时，为什么大鼠的肾上腺皮质病变会损害自发选择新对象而不是熟悉对象的自发能力的原因。该研究首先通过对延迟物体识别记忆的测试来重复这一标准发现。如预期的那样，周围神经皮层病变减少了新刺激与熟悉刺激的探索时间差异。相反，当先后测试新颖对象还是熟悉对象的优先探索时，即，当每个试验仅由新颖对象或仅熟悉对象组成时，具有周围神经皮层病变的同一只大鼠似乎表现正常。此外，没有迹象表明周围神经皮层病变会降低新奇物体的总探查水平，这是如果病变引起新的刺激看起来很熟悉就可以预测的。在一起的结果表明，在没有周围神经皮层组织的情况下，大鼠仍然可以接收物体新颖性​​的信号，尽管它们可能无法将该信息链接到适当的物体。因此，这些大鼠在区分对象新奇信号的来源方面受到损害，从而导致识别的同时选择测试不足。

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