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首页> 外文期刊>The European Journal of Neuroscience >Local field potentials are local events in the mouse auditory cortex
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Local field potentials are local events in the mouse auditory cortex

机译：局部场电位是小鼠听觉皮层中的局部事件

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Local field potentials (LFPs) and spikes (SPKs) sampled at the thalamocortical recipient layers represent the inputs from the thalamus and outputs to other layers. Previous studies have shown that SPK-constructed receptive fields (RFSPK) of cortical neurons are much smaller than LFP-constructed RFs (RFLFP). The difference in cortical RFLFP and RFSPK is therefore a plausible indication of local networking. The presence of a boarder RFLFP appears due to contamination, to some degree, from remote sites. Our studies of the mouse primary auditory cortex show that the best frequencies and minimum thresholds of RFSPK and RFLFP were similar. We also observed that the RFLFP area was only slightly larger than the RFSPK area, a very different finding from previous reports. The bandwidth of RFLFP was slightly broader than that of RFSPK at all levels. These data do not support the explanation that bioelectrical signals from distant sites impact on cortical LFP through volume conduction. That the cortical LFP represents a local event is further supported by comparisons of RFSPK and RFLFP after cortical inhibition by muscimol and cortical disinhibition by bicuculine. We conclude that the difference between RFSPK (output of cortical neurons) and RFLFP (input of cortical neurons) results from intracortical processing, including cortical lateral inhibition and excitation.
机译：在丘脑皮质受体层采样的局部场电势（LFP）和尖峰（SPK）代表了丘脑的输入和至其他层的输出。先前的研究表明，皮层神经元的SPK构造的感受野（RFSPK）比LFP构造的RF（RFLFP）小得多。因此，皮质RFLFP和RFSPK的差异是本地联网的合理指示。寄宿生RFLFP的出现是由于在一定程度上受到远程站点的污染所致。我们对小鼠初级听觉皮层的研究表明，RFSPK和RFLFP的最佳频率和最小阈值相似。我们还观察到RFLFP区域仅比RFSPK区域大一点，这与以前的报告有很大不同。在所有级别上，RFLFP的带宽都比RFSPK的带宽稍宽。这些数据不支持以下解释：来自远处的生物电信号通过体积传导影响皮质LFP。通过比较麝香酚对皮质的抑制作用和双cucuculine对皮质的抑制作用后，RFSPK和RFLFP的比较进一步证实了皮质LFP代表局部事件。我们得出结论，RFSPK（皮层神经元的输出）和RFLFP（皮层神经元的输入）之间的差异来自皮层内加工，包括皮层侧向抑制和兴奋。

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