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首页> 外文期刊>The European Journal of Neuroscience >Long-term, calorie-restricted intake of a high-fat diet in rats reduces impulse control and ventral striatal D-2 receptor signalling - two markers of addiction vulnerability
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Long-term, calorie-restricted intake of a high-fat diet in rats reduces impulse control and ventral striatal D-2 receptor signalling - two markers of addiction vulnerability

机译：长期限制卡路里摄入高脂饮食的大鼠可减少冲动控制和腹侧纹状体D-2受体信号传导-成瘾易感性的两个标志

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High impulsivity, mediated through ventral striatal dopamine signalling, represents an established risk factor for substance abuse, and may likewise confer vulnerability to pathological overeating. Mechanistically, the assumption is that trait impulsivity facilitates the initiation of maladaptive eating styles or choices. However, whether consumption of appetitive macronutrients themselves causes deficits in impulse control and striatal signalling, thereby contributing to cognitive changes permissive of overeating behaviour, has yet to be considered. We examined the effects of chronic maintenance on restricted equicaloric, but high-fat or high-sugar, diets (48 kcal/day; 60 kcal% fat or sucrose) on rats' performance in the five-choice serial reaction time task, indexing impulsivity and attention. Markers of dopamine signalling in the dorsal and ventral striatum, and plasma insulin and leptin levels, were also assessed. Rats maintained on the high-fat diet (HFD) were more impulsive, whereas the high-sugar diet (HSD) did not alter task performance. Importantly, body weight and hormone levels were similar between groups when behavioural changes were observed. Maintenance on HFD, but not on HSD, reduced the levels of dopamine D-2 receptor (D2R), cAMP response element-binding protein (CREB) and phosphophorylated CREB (Ser133) proteins in the ventral, but not dorsal, striatum. D2R expression in the ventral striatum also negatively correlated with impulsive responding, independently of diet. These data indicate that chronic exposure to even limited amounts of high-fat foods may weaken impulse control and alter neural signalling in a manner associated with vulnerability to addictions - findings that have serious implications for the propagation of uncontrolled eating behaviour in obesity and binge-eating disorder.
机译：通过腹侧纹状体多巴胺信号传导介导的高冲动性是药物滥用的既定危险因素，并且同样可能导致病理性暴饮暴食。从机械上讲，假设是特质冲动会促进不良适应饮食风格或选择的开始。但是，食用大量营养素本身是否会导致冲动控制和纹状体信号传导不足，从而导致允许过度饮食行为的认知变化，尚待研究。我们研究了长期维持对五卡路里连续反应时间任务中限制等热量但高脂或高糖饮食（48 kcal /天; 60 kcal％脂肪或蔗糖）的饮食对大鼠性能的影响。和关注。还评估了背侧和腹侧纹状体中多巴胺信号的标记，以及血浆胰岛素和瘦素水平。维持高脂饮食（HFD）的大鼠冲动性更高，而高糖饮食（HSD）不会改变任务表现。重要的是，观察到行为改变后，两组之间的体重和激素水平相似。维持HFD而非维持HSD可以降低腹侧纹状体而不是背侧纹状体中多巴胺D-2受体（D2R），cAMP反应元件结合蛋白（CREB）和磷酸化CREB（Ser133）蛋白的水平。与饮食无关，腹侧纹状体中的D2R表达也与冲动反应呈负相关。这些数据表明，即使长期食用有限量的高脂肪食物，也可能削弱成瘾者对冲动的控制能力，并改变神经信号的传递方式，这一发现严重影响了肥胖和暴饮暴食中不加控制的饮食行为的传播。紊乱。

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