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首页> 外文期刊>The European Journal of Neuroscience >Activity-dependent modulation of the axonal conduction of action potentials along rat hippocampal mossy fibers
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Activity-dependent modulation of the axonal conduction of action potentials along rat hippocampal mossy fibers

机译：沿着大鼠海马苔藓纤维的动作电位的轴突传导的活性依赖性调节

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The axonal conduction of action potentials in the nervous system is generally considered to be a stable signal for the relaying of information, and its dysfunction is involved in impairment of cognitive function. Recent evidence suggests that the conduction properties and excitability of axons are more variable than traditionally thought. To investigate possible changes in the conduction of action potentials along axons in the central nervous system, we recorded action potentials from granule cells that were evoked and conducted antidromically along unmyelinated mossy fibers in the rat hippocampus. To evaluate changes in axons by eliminating any involvement of changes in the somata, two latency values were obtained by stimulating at two different positions and the latency difference between the action potentials was measured. A conditioning electrical stimulus of 20 pulses at 1Hz increased the latency difference and this effect, which lasted for approximately 30s, was inhibited by the application of an -amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)/kainate receptor antagonist or a GluK1-containing kainate receptor antagonist, but not by an AMPA receptor-selective antagonist or an N-methyl-d-aspartate receptor antagonist. These results indicated that axonal conduction in mossy fibers is modulated in an activity-dependent manner through the activation of GluK1-containing kainate receptors. These dynamic changes in axonal conduction may contribute to the physiology and pathophysiology of the brain.
机译：神经系统中动作电位的轴突传导通常被认为是传递信息的稳定信号，其功能障碍与认知功能受损有关。最近的证据表明，轴突的传导特性和兴奋性比传统上认为的要多。为了研究中枢神经系统中沿着轴突的动作电位传导的可能变化，我们记录了由诱发并沿着大鼠海马中未髓鞘的苔藓纤维进行抗磷酸化的颗粒细胞产生的动作电位。为了通过消除躯体变化的任何参与来评估轴突的变化，通过在两个不同的位置进行刺激来获得两个潜伏时间值，并测量动作电位之间的潜伏时间差异。在1Hz处20脉冲的调节电刺激增加了潜伏期差异，并且通过应用-氨基-3-羟基-5-甲基异恶唑-4-丙酸酯（AMPA）/海藻酸酯受体抑制了持续约30s的效应。拮抗剂或含GluK1的海藻酸酯受体拮抗剂，但不能通过AMPA受体选择性拮抗剂或N-甲基-d-天冬氨酸受体拮抗剂。这些结果表明，通过激活含GluK1的海藻酸酯受体，以苔藓纤维中的轴突传导以活性依赖的方式被调节。轴突传导的这些动态变化可能有助于大脑的生理和病理生理。

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