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首页> 外文期刊>The European Journal of Neuroscience >The anabolic androgenic steroid, nandrolone decanoate, increases the density of Fos-like immunoreactive neurons in limbic regions of guinea-pig brain.
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The anabolic androgenic steroid, nandrolone decanoate, increases the density of Fos-like immunoreactive neurons in limbic regions of guinea-pig brain.

机译：合成代谢雄激素类固醇癸酸诺龙可增加豚鼠大脑边缘区域Fos样免疫反应性神经元的密度。

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The increased abuse of anabolic androgenic steroids is a major concern because of physiological and psychological side-effects. In some individuals they induce dramatic behavioural changes such as increased aggression, anxiety and depression. The mechanisms behind these behavioural changes are still poorly understood. In order to obtain information on the brain regions affected by anabolic androgenic steroids, the distribution of neurons containing c-Fos, the protein product of the immediate early gene c-fos, and Fos-related antigens was studied following chronic treatment of guinea-pigs with a high dose of nandrolone decanoate (15 mg/kg i.m. daily for 14 days). The behaviour of the guinea-pigs was monitored for 1 h each day. Animals treated with nandrolone exhibited a significantly greater incidence of biting behaviour during the 14 day treatment period than vehicle-treated animals. A significantly greater density of c-Fos and Fos-related antigen-positive neurons was found in the central nucleus of the amygdala, and of Fos-related antigen-positive neurons in the frontal cortex, the shell of the nucleus accumbens and the supraoptic nucleus in nandrolone-treated animals than in vehicle controls. Therefore, nandrolone induced Fos in brain regions involved in stress, behavioural responses and reward. The increased Fos expression in these limbic brain regions is of particular interest in relation to the behavioural changes reported in humans who abuse anabolic androgenic steroids and the abuse potential of these drugs.
机译：由于生理和心理方面的副作用，合成代谢雄激素类固醇的滥用增加是一个主要问题。在某些个体中，它们会引起剧烈的行为变化，例如攻击性增加，焦虑和沮丧。这些行为改变背后的机制仍知之甚少。为了获得有关合成代谢类固醇激素影响的大脑区域的信息，在对豚鼠进行长期治疗后，研究了含有c-Fos的神经元分布，即刻早期基因c-fos的蛋白质产物以及与Fos相关的抗原。高剂量的癸酸诺龙（每天15 mg / kg，连续14天）。每天监测豚鼠的行为1小时。与载体治疗的动物相比，用nandrolone治疗的动物在14天的治疗期内表现出明显更大的咬人行为。在杏仁核的中央核中，以及在额叶皮层，伏隔核的壳和视上核中的Fos相关的抗原阳性神经元的密度明显高于c-Fos和Fos相关的抗原阳性神经元的密度。在用nandrolone处理的动物中比在媒介物对照中。因此，nandrolone诱导与压力，行为反应和奖励有关的大脑区域的Fos。这些边缘脑区的Fos表达增加与滥用同化雄激素类固醇的人的行为变化以及这些药物的滥用潜力有关。

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