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首页> 外文期刊>The European Journal of Neuroscience >Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis.
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Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis.

机译：丰富的环境和体育活动会刺激海马体，但不会刺激嗅球神经发生。

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摘要

Exposure to an enriched environment and physical activity, such as voluntary running, increases neurogenesis of granule cells in the dentate gyrus of adult mice. These stimuli are also known to improve performance in hippocampus-dependent learning tasks, but it is unclear whether their effects on neurogenesis are exclusive to the hippocampal formation. In this study, we housed adult mice under three conditions (enriched environment, voluntary wheel running and standard housing), and analysed proliferation in the lateral ventricle wall and granule cell neurogenesis in the olfactory bulb in comparison to the dentate gyrus. Using bromodeoxyuridine to label dividing cells, we could not detect any difference in the number of newly generated cells in the ventricle wall. When giving the new cells time to migrate and differentiate in the olfactory bulb, we observed no changes in the number of adult-generated olfactory granule cells; however, voluntary running and enrichment produced a doubling in the amount ofnew hippocampal granule cells. The discrepancy between the olfactory bulb and the dentate gyrus suggests that these living conditions trigger locally through an as yet unidentified mechanism specific to neurogenic signals in the dentate gyrus.
机译：暴露于丰富的环境和体育活动中，例如自发奔跑，会增加成年小鼠齿状回中颗粒细胞的神经发生。还已知这些刺激可改善海马依赖性学习任务的表现，但尚不清楚它们对神经发生的影响是否仅在海马形成中起作用。在这项研究中，我们将成年小鼠置于三种条件下（富足环境，自动滚轮运行和标准住房），并分析了与齿状回相比，侧脑室壁的增殖和嗅球中颗粒细胞的神经发生。使用溴脱氧尿苷标记分裂细胞，我们无法检测到脑室壁中新生成的细胞数量有任何差异。当给新细胞在嗅球中迁移和分化的时间时，我们观察到成年产生的嗅觉颗粒细胞的数量没有变化。但是，自愿奔跑和富集产生的新海马颗粒细胞数量增加了一倍。嗅球与齿状回之间的差异表明，这些生活条件是通过尚未明确的，针对齿状回中神经源性信号的机制局部触发的。

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