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首页> 外文期刊>The European Journal of Neuroscience >Noxious-evoked c-fos expression in brainstem neurons immunoreactive for GABAB, micro -opioid and NK-1 receptors.
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Noxious-evoked c-fos expression in brainstem neurons immunoreactive for GABAB, micro -opioid and NK-1 receptors.

机译：有害诱发的c-fos在脑干神经元中对GABAB，微阿片类药物和NK-1受体具有免疫反应性。

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摘要

Modulation of nociceptive transmission at the brainstem involves several neurochemical systems. The precise location and specific characteristics of nociceptive neurons activated in each system was never reported. In this study, the presence of GABAB, micro -opioid, and neurokinin-1 (NK-1) receptors in brainstem nociceptive neurons was investigated by double-immunocytochemical detection of each receptor and noxious-evoked induction of the c-fos proto-oncogene. Noxious cutaneous mechanical stimulation significantly increased the proportions of neurons double-labelled for Fos and GABAB receptors in several brainstem regions, namely, the reticular formation of the caudal ventrolateral medulla (VLMlat and VLMrf), lateral reticular nucleus, spinal trigeminal nucleus, pars caudalis (Sp5C), nucleus of the solitary tract, dorsal reticular nucleus, ventral reticular nucleus, raphe obscurus nucleus and dorsal parabrachial nucleus (DPB). For micro -opioid receptors, the proportions of double-labelled neurons in noxious-stimulated animals were higher than in controls only in the VLMlat, VLMrf, Sp5C, DPB and A5 noradrenergic cell group. As for the NK-1 receptor, no significant differences were found between control and stimulated animals. According to these results, neurons expressing GABAB, micro -opioid and NK-1 receptors at several pain control centres of the brainstem are differentially involved in processing nociceptive mechanical input. The data provide the definition of new supraspinal targets for selective modulation of nociceptive neurons in order to define better strategies of pain control.
机译：脑干伤害感受传递的调节涉及多个神经化学系统。从未报道过在每个系统中激活的伤害性神经元的确切位置和特定特征。在这项研究中，通过双重免疫细胞化学检测每种受体和c-fos原癌基因的有害诱导，研究了脑干伤害感受性神经元中GABAB，微阿片类和神经激肽-1（NK-1）受体的存在。 。有害的皮肤机械刺激显着增加了脑干几个区域（即尾侧腹侧延髓的网状结构（VLMlat和VLMrf），网状外侧核，三叉神经核，脊par）的双标记Fos和GABAB受体的神经元的比例。 Sp5C），孤立道细胞核，背侧网状细胞核，腹侧网状细胞核，暗纹肌核和背臂旁臂核（DPB）。对于微阿片类受体，仅在VLMlat，VLMrf，Sp5C，DPB和A5去甲肾上腺素能细胞组中，有毒刺激的动物中双标记神经元的比例高于对照组。至于NK-1受体，在对照动物和受刺激的动物之间没有发现显着差异。根据这些结果，在脑干的几个疼痛控制中心表达GABAB，微阿片类药物和NK-1受体的神经元在处理伤害性机械输入中有差异。数据为选择性调节伤害感受性神经元提供了新的脊髓上目标的定义，以定义更好的疼痛控制策略。

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