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首页> 外文期刊>The European Journal of Neuroscience >Metabotropic glutamate receptor 5 (mGluR5)-mediated phosphoinositide hydrolysis and NMDA-potentiating effects are blunted in the striatum of aged rats: a possible additional mechanism in striatal senescence.
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Metabotropic glutamate receptor 5 (mGluR5)-mediated phosphoinositide hydrolysis and NMDA-potentiating effects are blunted in the striatum of aged rats: a possible additional mechanism in striatal senescence.

机译：代谢型谷氨酸受体5（mGluR5）介导的磷酸肌醇水解和NMDA增强作用在衰老大鼠的纹状体中减弱：纹状体衰老的可能的附加机制。

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摘要

The aim of the present work was to verify whether an impairment of subtype 5 metabotropic glutamate receptor-mediated neurotransmission did occur in the aged striatum. To this end, the ability of the subtype 5 metabotropic glutamate receptor agonist, RS-2-chloro-5-hydroxyphenylglycine, to stimulate phosphoinositide hydrolysis and to potentiate N-methyl-d-aspartate-induced effects in striatal slices from young (3 months) and aged (24 months) rats was compared. The ability of RS-2-chloro-5-hydroxyphenylglycine to induce maximal phosphoinositide turnover and to potentiate N-methyl-d-aspartate effects was significantly reduced in slices from old vs. young rats. These changes were associated with a significant reduction in the expression of subtype 5 metabotropic glutamate receptor protein (-28.8%) and phospholipase C-beta1 (-55.8%) in old striata, while receptor messenger ribonucleic acid expression was unchanged. These results show that the signalling associated with subtype 5 metabotropic glutamate receptors undergoes significant age-related changes and that a reduced expression of subtype 5 metabotropic glutamate receptors and, more importantly, phospholipase C-beta1 may account for the functional decline of subtype 5 metabotropic glutamate receptors.
机译：本工作的目的是验证在老年纹状体中是否确实发生了亚型5型代谢型谷氨酸受体介导的神经传递障碍。为此，亚型5代谢型谷氨酸受体激动剂RS-2-氯-5-羟苯基甘氨酸刺激年轻人的纹状体切片中磷酸肌醇水解并增强N-甲基-d-天冬氨酸诱导的作用（3个月） ）和成年（24个月）大鼠进行了比较。在老龄大鼠和幼龄大鼠的切片中，RS-2-氯-5-羟基苯基甘氨酸诱导最大的磷酸肌醇周转和增强N-甲基-d-天冬氨酸作用的能力显着降低。这些变化与旧纹状体中亚5型代谢型谷氨酸受体蛋白（-28.8％）和磷脂酶C-beta1（-55.8％）的表达显着降低有关，而受体信使核糖核酸的表达则保持不变。这些结果表明，与5型代谢型谷氨酸受体相关的信号转导经历了与年龄相关的显着变化，并且5型代谢型谷氨酸受体的表达减少，更重要的是，磷脂酶C-beta1可能解释了5型代谢型谷氨酸的功能下降。受体。

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